Ramatroban

Also known as: BAY u3405, Baynas, (3R)-3-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propionic acid, 3-((3R)-3-(((4-Fluorophenyl)sulfonyl)amino)-1,2,3,4-tetrahydro-9H-carbazol-9-yl)propanoic Acid, 9H-Carbazole-9-propanoic acid, 3-[[(4-fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-, (3R)-, CS-1350, MFCD00887606

Ramatroban (CAS 116649-85-5) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C21H21FN2O4S and a molecular weight of 416.466 g/mol. Key properties include a boiling point of 654.7±65.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 349.7±34.3 °C. It is classified under GHS with signal word Warning and hazard statements H315 — Causes skin irritation, H319 — Causes serious eye irritation and H335 — May cause respiratory irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 116649-85-5
Jingsj CID: J-1987549-1
Molecular Formula: C₂₁H₂₁FN₂O₄S
Molecular Weight: 416.466 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	654.7±65.0 °C at 760 mmHg
Density	1.4±0.1 g/cm3
Flash Point	349.7±34.3 °C
Exact Mass	416.120605
PSA	96.78000
LogP	4.09
Vapor Pressure	0.0±2.1 mmHg at 25°C
Refractive Index	1.664
Storage Conditions	Desiccate at -20°C

GHS Safety & Compliance

IrritantSignal word: Warning

H315 — Causes skin irritation
H319 — Causes serious eye irritation
H335 — May cause respiratory irritation

Activity & Biological Data

Target	hTP:14 nM (IC50) hDP2:311 nM (IC50) CYP 2C9:15 μM (IC50)
Additional Information	[1]. Stearns BA, et al. Novel tricyclic antagonists of the prostaglandin D 2 receptor DP2 with efficacy in a murine modelof allergic rhinitis. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4647-51. [2]. Sugimoto H, et al. An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D 2 -induced eosinophil migration in vitro. J Pharmacol Exp Ther. 2003 Apr;305(1):347-52. [3]. Haba R, et al. Central CRTH2, a second prostaglandin D 2 receptor, mediates emotional impairment in the lipopolysaccharide and tumor-induced sickness behavior model. J Neurosci. 2014 Feb 12;34(7):2514-23.

Target

hTP:14 nM (IC50) hDP2:311 nM (IC50) CYP 2C9:15 μM (IC50)

Additional Information

[1]. Stearns BA, et al. Novel tricyclic antagonists of the prostaglandin D 2 receptor DP2 with efficacy in a murine modelof allergic rhinitis. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4647-51. [2]. Sugimoto H, et al. An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D 2 -induced eosinophil migration in vitro. J Pharmacol Exp Ther. 2003 Apr;305(1):347-52. [3]. Haba R, et al. Central CRTH2, a second prostaglandin D 2 receptor, mediates emotional impairment in the lipopolysaccharide and tumor-induced sickness behavior model. J Neurosci. 2014 Feb 12;34(7):2514-23.

Frequently Asked Questions

What is the CAS number of Ramatroban?

The CAS number of Ramatroban is 116649-85-5.

What are the molecular formula and molecular weight of Ramatroban?

Ramatroban has molecular formula C21H21FN2O4S and molecular weight 416.466 g/mol.

Is Ramatroban hazardous?

Ramatroban has GHS signal word Warning and hazard statements H315 — Causes skin irritation; H319 — Causes serious eye irritation; H335 — May cause respiratory irritation.

What are the upstream and downstream products of Ramatroban?

For Ramatroban, Upstream Products: 1,2,4,9-Tetrahydro-carbazol-3-one, 1,4-Dioxaspiro[4.5]decan-8-one, Phenylhydrazine.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Ramatroban (CAS 116649-85-5)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1987549-1 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.