PI-103
Also known as: 3-(4-Morpholinopyrido[3',2':4,5] furo[3,2-d]pyriMidin-2-yl)phenol, 3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol, 3-(4-morpholinopyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl)phenol hydrochloride, 3-[4-(4-Morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenol hydrochloride (1:1), 3-[4-(4-Morpholinylpyrido[3',2',4,5]furo[3,2-d]pyrimidin-2-yl]phenol, 3-[4-(Morpholin-4-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenol hydrochloride (1:1), PI 3-Kinase Inhibitor (PI-103) B-0303, PI-103 - CAS 371935-74-9 - Calbiochem, PI-103, Free Base, >99%, PI-103HydrochlorideSalt, PI103, Phenol, 3-[4-(4-Morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyriMidin-2-yl]-, Phenol, 3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]-, hydrochloride (1:1), S1038_Selleck, X6K
PI-103 (CAS 371935-74-9) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C19H16N4O3 and a molecular weight of 348.36 g/mol. Key properties include a boiling point of 520.25ºC at 760 mmHg and a density of 1.409 g/cm3. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 371935-74-9
- Jingsj CID
- J-1987529-7
- Molecular Formula
- C19H16N4O3
- Molecular Weight
- 348.36 g/mol
- Category
- Organic Compounds
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Boiling Point | 520.25ºC at 760 mmHg |
|---|---|
| Density | 1.409 g/cm3 |
| PSA | 84.51000 |
| LogP | 3.84720 |
| Refractive Index | 1.712 |
| Storage Conditions | Desiccate at +4°C |
Activity & Biological Data
| Target | p110α:8 nM (IC50) p110β:88 nM (IC50) p110δ:48 nM (IC50) p110γ:150 nM (IC50) PI3KC2β:26 nM (IC50) PI3KC2α:1 μM (IC50) hsVPS34:2.3 μM (IC50) mTORC1:20 nM (IC50) mTORC2:83 nM (IC50) DNA-PK:2 nM (IC50) ATR:850 nM (IC50) ATM:920 nM (IC50) PI4KIIIβ:50 μM (IC50) |
|---|---|
| Additional Information | [1]. Raynaud FI, et al. Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103through PI-540, PI-620 to the oral agent GDC-0941. Mol Cancer Ther. 2009 Jul;8(7):1725-39. [2]. Park S, et al. PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase anLeukemia. 2008 Sep;22(9):1698-706.d mTOR, has antileukemicactivity in AmL. Leukemia. 2008 Sep;22(9):1698-706. [3]. López-Fauqued M, et al. The dual PI3K/mTOR inhibitor PI-103 promotes immunosuppression, in vivo tumor growth and increases survival of sorafenib-treated melanoma cells. Int J Cancer. 2010 Apr 1;126(7):1549-61. [4]. Knight ZA, et al. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 2006 May 19;125(4):733-47. |
Frequently Asked Questions
What is the CAS number of PI-103?
The CAS number of PI-103 is 371935-74-9.
What are the molecular formula and molecular weight of PI-103?
PI-103 has molecular formula C19H16N4O3 and molecular weight 348.36 g/mol.
What are the upstream and downstream products of PI-103?
For PI-103, Upstream Products: 2-(3-Methoxyphenyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-4(3H)-one, Ethyl 3-aminofuro[2,3-b]pyridine-2-carboxylate, 3-(3-Methoxybenzamido)furo[2,3-b]pyridine-2-carboxamide.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "PI-103 (CAS 371935-74-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1987529-7 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.