BAY 11-7082

Also known as: (E)-3-(4-Methylphenylsulfonyl)-2-propenenitrile, (E)-3-Tosylacrylonitrile, BAY 11-7821, BAY-11-7082, BAY11-7082, 3-(p-Toluenesulfonyl)acrylonitrile

BAY 11-7082 (CAS 19542-67-7) is a compound in the Aromatic Hydrocarbons category listed in the Jingsj chemical database. It has the molecular formula C10H9NO2S and a molecular weight of 207.249 g/mol. Key properties include a melting point of 133-135℃, a boiling point of 397.6±42.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 194.3±27.9 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 19542-67-7
Jingsj CID: J-1987508-2
Molecular Formula: C₁₀H₉NO₂S
Molecular Weight: 207.249 g/mol
Category: Aromatic Hydrocarbons
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	133-135℃
Boiling Point	397.6±42.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	194.3±27.9 °C
Exact Mass	207.035400
PSA	66.31000
LogP	1.28
Appearance	solid \| white
Vapor Pressure	0.0±0.9 mmHg at 25°C
Refractive Index	1.557
Storage Conditions	Store at +4°C
Additional Property	DMSO: 25 mg/mL, soluble

Activity & Biological Data

Target	NF-κB USP7:0.19 μM (IC50) USP21:0.96 μM (IC50) Autophagy
Additional Information	[1]. Mori N, et al. Bay 11-7082 inhibits transcription factor NF-kappaB and induces apoptosis of HTLV-I-infected T-cell lines andprimary adult T-cell leukemia cells. Blood. 2002 Sep 1;100(5):1828-1834. [2]. Ritorto MS, et al. Screening of DUB activity and specificity by MALDI-TOF mass spectrometry. Nat Commun. 2014 Aug 27;5:4763. [3]. Strickson S, et al. The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system. Biochem J. 2013 May 1;451(3):427-437. [4]. Pierce JW, et al. Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J Biol Chem. 1997 Aug 22;272(34):21096-103.

Target

NF-κB USP7:0.19 μM (IC50) USP21:0.96 μM (IC50) Autophagy

Additional Information

[1]. Mori N, et al. Bay 11-7082 inhibits transcription factor NF-kappaB and induces apoptosis of HTLV-I-infected T-cell lines andprimary adult T-cell leukemia cells. Blood. 2002 Sep 1;100(5):1828-1834. [2]. Ritorto MS, et al. Screening of DUB activity and specificity by MALDI-TOF mass spectrometry. Nat Commun. 2014 Aug 27;5:4763. [3]. Strickson S, et al. The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system. Biochem J. 2013 May 1;451(3):427-437. [4]. Pierce JW, et al. Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J Biol Chem. 1997 Aug 22;272(34):21096-103.

Frequently Asked Questions

What is the CAS number of BAY 11-7082?

The CAS number of BAY 11-7082 is 19542-67-7.

What are the molecular formula and molecular weight of BAY 11-7082?

BAY 11-7082 has molecular formula C10H9NO2S and molecular weight 207.249 g/mol.

What are the upstream and downstream products of BAY 11-7082?

For BAY 11-7082, Upstream Products: Sodium p-toluenesulfinate, Acrylonitrile, 2,3-Dibromopropionitrile; Downstream Products: 4-methylbenzenesulfonyl bromide.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "BAY 11-7082 (CAS 19542-67-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1987508-2 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.