6-Diazo-5-oxo-L-norleucine
Also known as: DON, L-DON, 6-DIAZO-5-OXO-NORLEUCINE, 6-DIAZO-5-OXO-L-2-AMINOHEXANOIC ACID, (S)-2-Amino-6-diazo-5-oxocaproic acid, H-6-DIAZO-5-OXO-L-NORLEUCINE, diazo-oxo-norleucine, MFCD00037218
6-Diazo-5-oxo-L-norleucine (CAS 157-03-9) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C6H9N3O3 and a molecular weight of 171.15400 g/mol. Key properties include a melting point of -145ºC (dec.), a boiling point of 301.12°C (rough estimate) and a density of 1.3994 (rough estimate). It is classified under GHS with signal word Danger and hazard statements H301 — Toxic if swallowed, H311 — Toxic in contact with skin and H331 — Toxic if inhaled. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 157-03-9
- Jingsj CID
- J-1987307-5
- Molecular Formula
- C6H9N3O3
- Molecular Weight
- 171.15400 g/mol
- Category
- Organic Acids
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | -145ºC (dec.) |
|---|---|
| Boiling Point | 301.12°C (rough estimate) |
| Density | 1.3994 (rough estimate) |
| Exact Mass | 171.06400 |
| PSA | 117.78000 |
| Appearance | crystalline | light yellow |
| Refractive Index | 1.5800 (estimate) |
| Storage Conditions | −20°C |
GHS Safety & Compliance
- H301 — Toxic if swallowed
- H311 — Toxic in contact with skin
- H331 — Toxic if inhaled
Activity & Biological Data
| Target | Ki: 6 μM (glutaminases)[4] |
|---|---|
| Additional Information | [1]. Kulkarni RM, et al. Evaluation of genetic toxicity of 6-diazo-5-oxo-l-norleucine (DON). Toxicol Mech Methods. 2017 Sep;27(7):518-527. [2]. Thangavelu K, et al. Structural basis for the active site inhibition mechanism of human kidney-type glutaminase (KGA). Sci Rep. 2014 Jan 23;4:3827. [3]. Willis RC, et al. The inhibition by 6-diazo-5-oxo-l-norleucine of glutamine catabolism of the cultured human lymphoblast. J Cell Physiol. 1977 Dec;93(3):375-82. [4]. Sharma NS, et al. Targeting tumor-intrinsic hexosamine biosynthesis sensitizes pancreatic cancer to anti-PD1 therapy. J Clin Invest. 2019 Oct 15. |
Customs & Trade Information
| HS Code | 2927000090 |
|---|---|
| Summary | 2927000090 other diazo-, azo- or azoxy-compounds。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
Frequently Asked Questions
What is the CAS number of 6-Diazo-5-oxo-L-norleucine?
The CAS number of 6-Diazo-5-oxo-L-norleucine is 157-03-9.
What are the molecular formula and molecular weight of 6-Diazo-5-oxo-L-norleucine?
6-Diazo-5-oxo-L-norleucine has molecular formula C6H9N3O3 and molecular weight 171.15400 g/mol.
Is 6-Diazo-5-oxo-L-norleucine hazardous?
6-Diazo-5-oxo-L-norleucine has GHS signal word Danger and hazard statements H301 — Toxic if swallowed; H311 — Toxic in contact with skin; H331 — Toxic if inhaled.
What are the upstream and downstream products of 6-Diazo-5-oxo-L-norleucine?
For 6-Diazo-5-oxo-L-norleucine, Upstream Products: L-Glutamic acid, N-Phthaloyl-L-glutamic anhydride, gamma-Benzyl L-glutamate.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "6-Diazo-5-oxo-L-norleucine (CAS 157-03-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1987307-5 (accessed 2026-11-06).
Data for reference only; verify product details with suppliers before purchase.