Epoxomicin

Also known as: BU-4061T, N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]-L-threoninamide, Epoxomicin (BU-4061T)

Epoxomicin (CAS 134381-21-8) is a compound in the Ethers category listed in the Jingsj chemical database. It has the molecular formula C28H50N4O7 and a molecular weight of 554.719 g/mol. Key properties include a melting point of 107-109ºC, a boiling point of 795.7±60.0 °C at 760 mmHg, a density of 1.1±0.1 g/cm3 and a flash point of 435.0±32.9 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 134381-21-8
Jingsj CID: J-1987247-8
Molecular Formula: C₂₈H₅₀N₄O₇
Molecular Weight: 554.719 g/mol
Category: Ethers
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	107-109ºC
Boiling Point	795.7±60.0 °C at 760 mmHg
Density	1.1±0.1 g/cm3
Flash Point	435.0±32.9 °C
Exact Mass	554.367920
PSA	157.44000
LogP	3.32
Vapor Pressure	0.0±6.3 mmHg at 25°C
Refractive Index	1.504
Storage Conditions	-20°C

Activity & Biological Data

Additional Information	[1]. Kim KB, et al. Proteasome inhibition by the natural products epoxomicin and dihydroeponemycin: insights into specificity and potency. Bioorg Med Chem Lett. 1999 Dec 6;9(23):3335-40. [2]. Hanada M, et al. Epoxomicin, a new antitumor agent of microbial origin. J Antibiot (Tokyo). 1992 Nov;45(11):1746-52. [3]. Garrett IR, et al. Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro. J Clin Invest. 2003 Jun;111(11):1771-82. [4]. McNaught KS, et al. Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease. Ann Neurol. 2004 Jul;56(1):149-62. [5]. Rideout HJ, et al. Dopaminergic neurons in rat ventral midbrain cultures undergo selective apoptosis and form inclusions, but do not up-regulate iHSP70, following proteasomal inhibition. J Neurochem. 2005 Jun;93(5):1304-13.

Additional Information

[1]. Kim KB, et al. Proteasome inhibition by the natural products epoxomicin and dihydroeponemycin: insights into specificity and potency. Bioorg Med Chem Lett. 1999 Dec 6;9(23):3335-40. [2]. Hanada M, et al. Epoxomicin, a new antitumor agent of microbial origin. J Antibiot (Tokyo). 1992 Nov;45(11):1746-52. [3]. Garrett IR, et al. Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro. J Clin Invest. 2003 Jun;111(11):1771-82. [4]. McNaught KS, et al. Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease. Ann Neurol. 2004 Jul;56(1):149-62. [5]. Rideout HJ, et al. Dopaminergic neurons in rat ventral midbrain cultures undergo selective apoptosis and form inclusions, but do not up-regulate iHSP70, following proteasomal inhibition. J Neurochem. 2005 Jun;93(5):1304-13.

Frequently Asked Questions

What is the CAS number of Epoxomicin?

The CAS number of Epoxomicin is 134381-21-8.

What are the molecular formula and molecular weight of Epoxomicin?

Epoxomicin has molecular formula C28H50N4O7 and molecular weight 554.719 g/mol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Epoxomicin (CAS 134381-21-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1987247-8 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.