Tafluprost acid

Also known as: AFP-172, 9alpha,11alpha-dihydroxy-15,15-difluoro-16-phenoxy-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-oic acid, Tafluprost (free acid), 7-[2-(3,3-difluoro-4-phenoxybut-1-enyl)-3,5-dihydroxycyclopentyl]hept-5-enoic acid, (5Z)-7-{(1R,2R,3R,5S)-2-[(1E)-3,3-difluoro-4-phenoxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl}-5-heptenoic acid

Tafluprost acid (CAS 209860-88-8) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C22H28F2O5 and a molecular weight of 410.452 g/mol. Key properties include a boiling point of 575.9±50.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 302.1±30.1 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 209860-88-8
Jingsj CID: J-1987231-1
Molecular Formula: C₂₂H₂₈F₂O₅
Molecular Weight: 410.452 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	575.9±50.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	302.1±30.1 °C
Exact Mass	410.190491
PSA	86.99000
LogP	2.80
Vapor Pressure	0.0±1.7 mmHg at 25°C
Refractive Index	1.579

Activity & Biological Data

Target	Human FP Receptor:0.4 nM (Ki) Human FP Receptor:0.53 nM (EC50) EP3 Receptor:67 nM (IC50)
Additional Information	[1]. Takagi Y, et al. Pharmacological characteristics of AFP-168 (tafluprost), a new prostanoid FP receptor agonist, as an ocular hypotensive drug. Exp Eye Res. 2004 Apr;78(4):767-76. [2]. Taketani Y, et al. Activation of the prostanoid FP receptor inhibits adipogenesis leading to deepening of the upper eyelid sulcus in prostaglandin-associated periorbitopathy. Invest Ophthalmol Vis Sci. 2014 Mar 4;55(3):1269-76. [3]. Fuwa M, et al. Advantages of Efficacy and Safety of Fixed-Dose Tafluprost/Timolol Combination Over Fixed-Dose Latanoprost/Timolol Combination. PLoS One. 2016 Jul 6;11(7):e0158797. [4]. Roh YJ, et al. Effects of AFP-172 on COX-2-induced angiogenic activities on human umbilical vein endothelial cells. Graefes Arch Clin Exp Ophthalmol. 2012 Dec;250(12):1765-75.

Target

Human FP Receptor:0.4 nM (Ki) Human FP Receptor:0.53 nM (EC50) EP3 Receptor:67 nM (IC50)

Additional Information

[1]. Takagi Y, et al. Pharmacological characteristics of AFP-168 (tafluprost), a new prostanoid FP receptor agonist, as an ocular hypotensive drug. Exp Eye Res. 2004 Apr;78(4):767-76. [2]. Taketani Y, et al. Activation of the prostanoid FP receptor inhibits adipogenesis leading to deepening of the upper eyelid sulcus in prostaglandin-associated periorbitopathy. Invest Ophthalmol Vis Sci. 2014 Mar 4;55(3):1269-76. [3]. Fuwa M, et al. Advantages of Efficacy and Safety of Fixed-Dose Tafluprost/Timolol Combination Over Fixed-Dose Latanoprost/Timolol Combination. PLoS One. 2016 Jul 6;11(7):e0158797. [4]. Roh YJ, et al. Effects of AFP-172 on COX-2-induced angiogenic activities on human umbilical vein endothelial cells. Graefes Arch Clin Exp Ophthalmol. 2012 Dec;250(12):1765-75.

Frequently Asked Questions

What is the CAS number of Tafluprost acid?

The CAS number of Tafluprost acid is 209860-88-8.

What are the molecular formula and molecular weight of Tafluprost acid?

Tafluprost acid has molecular formula C22H28F2O5 and molecular weight 410.452 g/mol.

What are the upstream and downstream products of Tafluprost acid?

For Tafluprost acid, Upstream Products: (4-Carboxybutyl)triphenylphosphonium bromide, Dimethyl (2-oxo-3-phenoxypropyl)phosphonate, (-)-Corey aldehyde benzoate.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Tafluprost acid (CAS 209860-88-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1987231-1 (accessed 2026-11-07).

Data for reference only; verify product details with suppliers before purchase.