BMS-536924

Also known as: 4-[[(2S)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]-3-[4-methyl-6-(4-morpholinyl)-1H-benzimidazol-2-yl]-2(1H)-pyridinone, (S)-4-((2-(3-chlorophenyl)-2-hydroxyethyl)amino)-3-(4-methyl-6-morpholino-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one, 4-[[(2S)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]-3-[7-methyl-5-(4-morpholinyl)-1H-benzimidazol-2-yl]-2(1H)-pyridinone, BMS 536924, BMS536924, Insulin-like Growth Factor-1 Receptor Inhibitor, CDK inhibitor, CHEMBL401930, NSC761760, HY-10262

BMS-536924 (CAS 468740-43-4) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C25H26ClN5O3 and a molecular weight of 479.959 g/mol. Key property: a density of 1.4±0.1 g/cm3. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 468740-43-4
Jingsj CID: J-1986948-8
Molecular Formula: C₂₅H₂₆ClN₅O₃
Molecular Weight: 479.959 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Density	1.4±0.1 g/cm3
Exact Mass	479.172424
PSA	106.27000
LogP	2.61
Refractive Index	1.717
Storage Conditions	-20℃

Activity & Biological Data

Additional Information	[1]. Wittman M, et al. Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity. J Med Chem. 2005 Sep 8;48(18):5639-43. [2]. Litzenburger BC, et al. BMS-536924 reverses IGF-IR-induced transformation of mammary epithelial cells and causes growth inhibition and polarization of MCF7 cells. Clin Cancer Res. 2009 Jan 1;15(1):226-37. [3]. Ohashi H, et al. Insulin-like growth factor receptor expression is associated with aggressive phenotypes and has therapeutic activity in biliary tract cancers. Cancer Sci. 2012 Feb;103(2):252-61.

Additional Information

[1]. Wittman M, et al. Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity. J Med Chem. 2005 Sep 8;48(18):5639-43. [2]. Litzenburger BC, et al. BMS-536924 reverses IGF-IR-induced transformation of mammary epithelial cells and causes growth inhibition and polarization of MCF7 cells. Clin Cancer Res. 2009 Jan 1;15(1):226-37. [3]. Ohashi H, et al. Insulin-like growth factor receptor expression is associated with aggressive phenotypes and has therapeutic activity in biliary tract cancers. Cancer Sci. 2012 Feb;103(2):252-61.

Frequently Asked Questions

What is the CAS number of BMS-536924?

The CAS number of BMS-536924 is 468740-43-4.

What are the molecular formula and molecular weight of BMS-536924?

BMS-536924 has molecular formula C25H26ClN5O3 and molecular weight 479.959 g/mol.

What are the upstream and downstream products of BMS-536924?

For BMS-536924, Upstream Products: 2-Methyl-4-morpholino-6-nitroaniline, 4-Bromo-2-methyl-6-nitroaniline, 2-Chloro-1-(3-chlorophenyl)ethanone.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "BMS-536924 (CAS 468740-43-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1986948-8 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.