Oprozomib (ONX 0912)

Also known as: 4,5-Anhydro-1,2-dideoxy-4-methyl-2-({O-methyl-N-[(2-methyl-1,3-thiazol-5-yl)carbonyl]-L-seryl-O-methyl-L-seryl}amino)-1-phenyl-D-erythro-pent-3-ulose, CS-696, D-erythro-3-Pentulose, 4,5-anhydro-1,2-dideoxy-4-C-methyl-2-[[O-methyl-N-[(2-methyl-5-thiazolyl)carbonyl]-L-seryl-O-methyl-L-seryl]amino]-1-phenyl-, LY335979 ONX-0912, N-[(2S)-3-methoxy-1-[[(2S)-3-methoxy-1-[[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]-2-methyl-1,3-thiazole-5-carboxamide, O-Methyl-N-[(2-methyl-5-thiazolyl)carbonyl]-L-seryl-O-methyl-N-[(1S)-2-[(2R)-2-methyl-2-oxiranyl]-2-oxo-1-(phenylmethyl)ethyl]-L-serinamide, ONX 0912, ONX-0912, OprozoMib, OprozoMib (ONX-0912), Ortho-Methyl-N-[(2-Methyl-5-Thiazolyl)Carbonyl]- L-Seryl-Ortho-Methyl-N-[(1s)-2-[(2r)-2-Methyl-2- Oxiranyl]-L-Serinamide, PR-047, QC-9273

Oprozomib (ONX 0912) (CAS 935888-69-0) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C25H32N4O7S and a molecular weight of 532.609 g/mol. Key properties include a boiling point of 849.9±65.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 467.8±34.3 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 935888-69-0
Jingsj CID: J-1986907-9
Molecular Formula: C₂₅H₃₂N₄O₇S
Molecular Weight: 532.609 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

Request MSDS / TDS

No offers for this compound yet.

Request a quote

Physicochemical Properties

Boiling Point	849.9±65.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	467.8±34.3 °C
Exact Mass	532.199158
PSA	186.96000
LogP	2.79
Vapor Pressure	0.0±3.2 mmHg at 25°C
Refractive Index	1.573
Storage Conditions	-20℃

Activity & Biological Data

Additional Information	[1]. Zhou HJ, et al. Design and synthesis of an orally bioavailable and selective peptide epoxyketone proteasome inhibitor (PR-047). J Med Chem. 2009 May 14;52(9):3028-38. [2]. Chauhan D, et al. A novel orally active proteasome inhibitor ONX 0912 triggers in vitro and in vivo cytotoxicity in multiple myeloma. Blood, 2010, 116(23), 4906-4915. [3]. Muchamuel T, et al. A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis. Nat Med, 2009, 15(7), 781-787.

Additional Information

[1]. Zhou HJ, et al. Design and synthesis of an orally bioavailable and selective peptide epoxyketone proteasome inhibitor (PR-047). J Med Chem. 2009 May 14;52(9):3028-38. [2]. Chauhan D, et al. A novel orally active proteasome inhibitor ONX 0912 triggers in vitro and in vivo cytotoxicity in multiple myeloma. Blood, 2010, 116(23), 4906-4915. [3]. Muchamuel T, et al. A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis. Nat Med, 2009, 15(7), 781-787.

Frequently Asked Questions

What is the CAS number of Oprozomib (ONX 0912)?

The CAS number of Oprozomib (ONX 0912) is 935888-69-0.

What are the molecular formula and molecular weight of Oprozomib (ONX 0912)?

Oprozomib (ONX 0912) has molecular formula C25H32N4O7S and molecular weight 532.609 g/mol.

What are the upstream and downstream products of Oprozomib (ONX 0912)?

For Oprozomib (ONX 0912), Upstream Products: 2-Methyl-1,3-thiazole-5-carboxylic acid, Ethyl 2-methylthiazole-5-carboxylate.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Oprozomib (ONX 0912) (CAS 935888-69-0)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1986907-9 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.