Ropinirole hydrochloride

Also known as: 4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one hydrochloride, 4-(2-Dipropylaminoethyl)-1,3-dihydroindol-2-one hydrochloride, SKF-101468A, Requip

Ropinirole hydrochloride (CAS 91374-20-8) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C16H25ClN2O and a molecular weight of 296.836 g/mol. Key properties include a melting point of 241-243ºC and a boiling point of 410.5ºC at 760mmHg. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed and H400 — Very toxic to aquatic life. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 91374-20-8
Jingsj CID: J-1986846-3
Molecular Formula: C₁₆H₂₅ClN₂O
Molecular Weight: 296.836 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	241-243ºC
Boiling Point	410.5ºC at 760mmHg
Exact Mass	296.165527
PSA	32.34000
LogP	3.78570
Storage Conditions	Room temp

GHS Safety & Compliance

Irritant / Environmental HazardSignal word: Warning

H302 — Harmful if swallowed
H400 — Very toxic to aquatic life

Activity & Biological Data

Additional Information	[1]. Eden, R.J., et al., Preclinical pharmacology of ropinirole (SK&F 101468-A) a novel dopamine D2 agonist. Pharmacol Biochem Behav, 1991. 38(1): p. 147-54. [2]. Iida, M., et al., Dopamine D2 receptor-mediated antioxidant and neuroprotective effects of ropinirole, a dopamine agonist. Brain Res, 1999. 838(1-2): p. 51-9. [3]. Lam, Y.W., Clinical pharmacology of dopamine agonists. Pharmacotherapy, 2000. 20(1 Pt 2): p. 17S-25S. [4]. Allen, R., et al., Ropinirole decreases periodic leg movements and improves sleep parameters in patients with restless legs syndrome. Sleep, 2004. 27(5): p. 907-14.

Additional Information

[1]. Eden, R.J., et al., Preclinical pharmacology of ropinirole (SK&F 101468-A) a novel dopamine D2 agonist. Pharmacol Biochem Behav, 1991. 38(1): p. 147-54. [2]. Iida, M., et al., Dopamine D2 receptor-mediated antioxidant and neuroprotective effects of ropinirole, a dopamine agonist. Brain Res, 1999. 838(1-2): p. 51-9. [3]. Lam, Y.W., Clinical pharmacology of dopamine agonists. Pharmacotherapy, 2000. 20(1 Pt 2): p. 17S-25S. [4]. Allen, R., et al., Ropinirole decreases periodic leg movements and improves sleep parameters in patients with restless legs syndrome. Sleep, 2004. 27(5): p. 907-14.

Customs & Trade Information

HS Code	2933790090
Summary	2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Ropinirole hydrochloride?

The CAS number of Ropinirole hydrochloride is 91374-20-8.

What are the molecular formula and molecular weight of Ropinirole hydrochloride?

Ropinirole hydrochloride has molecular formula C16H25ClN2O and molecular weight 296.836 g/mol.

Is Ropinirole hydrochloride hazardous?

Ropinirole hydrochloride has GHS signal word Warning and hazard statements H302 — Harmful if swallowed; H400 — Very toxic to aquatic life.

What are the upstream and downstream products of Ropinirole hydrochloride?

For Ropinirole hydrochloride, Upstream Products: 2-[2-(Dipropylamino)ethyl]-6-nitrophenylacetic acid hydrochloride, Dipropylamine, 4-(2-Bromoethyl)-1,3-dihydro-2H-indolin-2-one; Downstream Products: Ropinirole.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Ropinirole hydrochloride (CAS 91374-20-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1986846-3 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.