Gandotinib

Also known as: LY2784544, 3-[(4-chloro-2-fluorophenyl)methyl]-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(4-morpholinylmethyl)imidazo[1,2-b]pyridazin-6-amine, CC-18, Gandotinib (LY2784544), S2179_Selleck

Gandotinib (CAS 1229236-86-5) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C23H25ClFN7O and a molecular weight of 469.942 g/mol. Key property: a density of 1.5±0.1 g/cm3. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 1229236-86-5
Jingsj CID: J-1986780-2
Molecular Formula: C₂₃H₂₅ClFN₇O
Molecular Weight: 469.942 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Density	1.5±0.1 g/cm3
Exact Mass	469.179321
PSA	86.60000
LogP	2.39
Refractive Index	1.700
Storage Conditions	-20°C

Activity & Biological Data

Target	JAK2:3 nM (IC50) FGFR2:32 nM (IC50) Flt-4:25 nM (IC50) Tyk2:44 nM (IC50) JAK3:48 nM (IC50) FGFR3:106 nM (IC50) KDR:109 nM (IC50) FLT3:4 nM (IC50) TRKB:95 nM (IC50) ALK:138 nM (IC50) MUSK:147 nM (IC50) AURKA:168 nM (IC50) MAP3K9:299 nM (IC50)
Additional Information	[1]. Ma L, et al. Discovery and characterization of LY2784544, a small-molecule tyrosine kinase inhibitor of JAK2V617F. Blood Cancer J. 2013, 3, e109.

Frequently Asked Questions

What is the CAS number of Gandotinib?

The CAS number of Gandotinib is 1229236-86-5.

What are the molecular formula and molecular weight of Gandotinib?

Gandotinib has molecular formula C23H25ClFN7O and molecular weight 469.942 g/mol.

What are the upstream and downstream products of Gandotinib?

For Gandotinib, Upstream Products: (4-Chloro-2-fluorophenyl)(6-chloro-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-3-yl)methanone, 4'-Chloro-2'-fluoroacetophenone.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Gandotinib (CAS 1229236-86-5)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1986780-2 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.