Talnetant

Also known as: SB 223412, SB-223412, SB223412, CS-1123, UNII-CZ3T9T146K, 3-hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamide, (S)-N-(1-Phenylpropyl)-3-hydroxy-2-phenylquinoline-4-carboxamide, (-)-(S)-N-(alpha-ethylbenzyl)-3-hydroxy-2-phenylquinoline-4-carboxamide, 3-hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide, N-[(S)-α-ethylbenzyl]-3-hydroxy-2-phenylcinchoninamide

Talnetant (CAS 174636-32-9) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C25H22N2O2 and a molecular weight of 382.45400 g/mol. Key properties include a boiling point of 580.4ºC at 760mmHg, a density of 1.212g/cm3 and a flash point of 304.8ºC. It is classified under GHS with signal word Danger and hazard statements H301 — Toxic if swallowed. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 174636-32-9
Jingsj CID: J-1986654-7
Molecular Formula: C₂₅H₂₂N₂O₂
Molecular Weight: 382.45400 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	580.4ºC at 760mmHg
Density	1.212g/cm3
Flash Point	304.8ºC
Exact Mass	382.16800
PSA	65.71000
LogP	6.06330
Vapor Pressure	4.51E-14mmHg at 25°C
Refractive Index	1.657
Storage Conditions	2-8℃

GHS Safety & Compliance

Acute ToxicitySignal word: Danger

H301 — Toxic if swallowed

Activity & Biological Data

Additional Information	[1]. Giardina GA, et al. Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 2. Identification of (S)-N-(1-phenylpropyl)-3-hydroxy-2-phenylquinoline-4-carboxamide (SB 223412). J Med Chem. 1999 Mar 25;42(6):1053- [2]. Houghton LA, et al. Effect of the NK(3) receptor antagonist, talnetant, on rectal sensory function and compliance in healthy humans. Neurogastroenterol Motil. 2007 Sep;19(9):732-43. [3]. Dawson LA, et al. In vitro and in vivo characterization of the non-peptide NK3 receptor antagonist SB-223412 (talnetant): potential therapeutic utility in the treatment of schizophrenia. Neuropsychopharmacology. 2008 Jun;33(7):1642-52.

Additional Information

[1]. Giardina GA, et al. Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 2. Identification of (S)-N-(1-phenylpropyl)-3-hydroxy-2-phenylquinoline-4-carboxamide (SB 223412). J Med Chem. 1999 Mar 25;42(6):1053- [2]. Houghton LA, et al. Effect of the NK(3) receptor antagonist, talnetant, on rectal sensory function and compliance in healthy humans. Neurogastroenterol Motil. 2007 Sep;19(9):732-43. [3]. Dawson LA, et al. In vitro and in vivo characterization of the non-peptide NK3 receptor antagonist SB-223412 (talnetant): potential therapeutic utility in the treatment of schizophrenia. Neuropsychopharmacology. 2008 Jun;33(7):1642-52.

Frequently Asked Questions

What is the CAS number of Talnetant?

The CAS number of Talnetant is 174636-32-9.

What are the molecular formula and molecular weight of Talnetant?

Talnetant has molecular formula C25H22N2O2 and molecular weight 382.45400 g/mol.

Is Talnetant hazardous?

Talnetant has GHS signal word Danger and hazard statements H301 — Toxic if swallowed.

What are the upstream and downstream products of Talnetant?

For Talnetant, Upstream Products: Oxycinchophen, (S)-(-)-1-Phenylpropylamine, 2-Methoxyacetophenone.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Talnetant (CAS 174636-32-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1986654-7 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.