Apalutamide

Also known as: ARN-509, ARN509, JNJ-56021927, 4-[7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl]-2-fluoro-N-methylbenzamide

Apalutamide (CAS 956104-40-8) is a compound in the Organic Bases category listed in the Jingsj chemical database. It has the molecular formula C21H15F4N5O2S and a molecular weight of 477.435 g/mol. Key property: a density of 1.6±0.1 g/cm3. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 956104-40-8
Jingsj CID: J-1986633-2
Molecular Formula: C₂₁H₁₅F₄N₅O₂S
Molecular Weight: 477.435 g/mol
Category: Organic Bases
Last updated: 8/21/2026

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Physicochemical Properties

Density	1.6±0.1 g/cm3
Exact Mass	477.088257
PSA	121.42000
LogP	1.30
Refractive Index	1.659
Storage Conditions	-20°C

Activity & Biological Data

Target	IC50: 16 nM (Androgen receptor)[1]
Additional Information	[1]. Clegg NJ, et al. ARN-509: a novel antiandrogen for prostate cancer treatment. Cancer Res. 2012 Mar 15;72(6):1494-503. [2]. Smith MR, et al. Phase 2 Study of the Safety and Antitumor Activity of Apalutamide (ARN-509), a Potent Androgen Receptor Antagonist, in the High-risk Nonmetastatic Castration-resistant Prostate Cancer Cohort. Eur Urol. 2016 May 6. pii: S0302-2838(16)30133

Frequently Asked Questions

What is the CAS number of Apalutamide?

The CAS number of Apalutamide is 956104-40-8.

What are the molecular formula and molecular weight of Apalutamide?

Apalutamide has molecular formula C21H15F4N5O2S and molecular weight 477.435 g/mol.

What are the upstream and downstream products of Apalutamide?

For Apalutamide, Upstream Products: 5-amino-3-(trifluoromethyl)picolinonitrile, 4-((1-Cyanocyclobutyl)amino)-2-fluoro-N-methylbenzamide, Thiophosgene.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Apalutamide (CAS 956104-40-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1986633-2 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.