GW3965 hydrochloride

Also known as: GW-3965 hydrochloride, GW 3965 hydrochloride, 3-[3-[N-(2-Chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propoxy]phenylacetic acid hydrochloride, 3-[3-[[[2-Chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]benzeneacetic acid hydrochloride, 2-[3-[3-[[2-Chloro-3-(trifluoromethyl)phenyl]methyl-(2,2-diphenylethyl)amino]propoxy]phenyl]acetic acid hydrochloride, [3-(3-{[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino}propoxy)phenyl]acetic acid hydrochloride, UNII-6JI5YOG7RC

GW3965 hydrochloride (CAS 405911-09-3) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C33H31ClF3NO3 and a molecular weight of 582.052 g/mol. Key properties include a boiling point of 672.4±55.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 360.5±31.5 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 405911-09-3
Jingsj CID: J-1985911-1
Molecular Formula: C₃₃H₃₁ClF₃NO₃
Molecular Weight: 582.052 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	672.4±55.0 °C at 760 mmHg
Density	1.3±0.1 g/cm3
Flash Point	360.5±31.5 °C
Exact Mass	581.194458
PSA	49.77000
LogP	8.20
Vapor Pressure	0.0±2.2 mmHg at 25°C
Refractive Index	1.583
Storage Conditions	2-8℃

Activity & Biological Data

Target	EC50: 190 nM (hLXRα), 30 nM (hLXRβ)
Additional Information	[1]. Mitro, Nico., et al. LXR and TSPO as new therapeutic targets to increase the levels of neuroactive steroids in the central nervous system of diabetic animals. Neurochemistry International (2012), 60(6), 616-621. [2]. Guo, Deliang., et al. An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR-Dependent Pathway. Cancer Discovery (2011), 1(5), 442-456. [3]. Spyridon, Michael., et al. LXR as a novel antithrombotic target. Blood (2011), 117(21), 5751-5761.

Target

EC50: 190 nM (hLXRα), 30 nM (hLXRβ)

Additional Information

[1]. Mitro, Nico., et al. LXR and TSPO as new therapeutic targets to increase the levels of neuroactive steroids in the central nervous system of diabetic animals. Neurochemistry International (2012), 60(6), 616-621. [2]. Guo, Deliang., et al. An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR-Dependent Pathway. Cancer Discovery (2011), 1(5), 442-456. [3]. Spyridon, Michael., et al. LXR as a novel antithrombotic target. Blood (2011), 117(21), 5751-5761.

Frequently Asked Questions

What is the CAS number of GW3965 hydrochloride?

The CAS number of GW3965 hydrochloride is 405911-09-3.

What are the molecular formula and molecular weight of GW3965 hydrochloride?

GW3965 hydrochloride has molecular formula C33H31ClF3NO3 and molecular weight 582.052 g/mol.

What are the upstream and downstream products of GW3965 hydrochloride?

For GW3965 hydrochloride, Upstream Products: 2,2-Diphenylethylamine, 2-Chloro-3-(trifluoromethyl)benzaldehyde, 3-Bromo-1-propanol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "GW3965 hydrochloride (CAS 405911-09-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1985911-1 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.