Tolvaptan
Also known as: N-[4-(9-chloro-6-hydroxy-2-azabicyclo[5.4.0]undeca-8,10,12-triene-2-carbonyl)-3-methyl-phenyl]-2-methyl-benzamide, OPC-41061, Tolvaptan Tablets, OPC 41061, N-[4-[(5R)-7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl]-3-methylphenyl]-2-methylbenzamide, N-(4-{[(5R)-7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl}-3-Methylphenyl)-2-MethylbenzaMide, Samsca, UNII-21G72T1950, olvaptan, N-{4-[(7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl}-2-methylbenzamide, Benzamide, N-[4-[(7-chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methyl-, (±)-4'-[(7-chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-o-tolu-m-toluidide, benzazepine derivative,32
Tolvaptan (CAS 150683-30-0) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C26H25ClN2O3 and a molecular weight of 448.941 g/mol. Key properties include a melting point of 219-222°C, a boiling point of 594.4±50.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 313.3±30.1 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 150683-30-0
- Jingsj CID
- J-1985187-7
- Molecular Formula
- C26H25ClN2O3
- Molecular Weight
- 448.941 g/mol
- Category
- Organic Compounds
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 219-222°C |
|---|---|
| Boiling Point | 594.4±50.0 °C at 760 mmHg |
| Density | 1.3±0.1 g/cm3 |
| Flash Point | 313.3±30.1 °C |
| Exact Mass | 448.155365 |
| PSA | 69.64000 |
| LogP | 4.09 |
| Appearance | white to tan |
| Vapor Pressure | 0.0±1.8 mmHg at 25°C |
| Refractive Index | 1.664 |
| Storage Conditions | Refrigerator |
| Additional Property | DMSO: ≥15mg/mL |
Activity & Biological Data
| Additional Information | [1]. Friedman B, Cirulli J.Hyponatremia in critical care patients: Frequency, outcome, characteristics, and treatment with the vasopressin V(2)-receptor antagonist tolvaptan.J Crit Care. 2012 Aug 8. [2]. Inomata T.Tolvaptan (vasopressin receptor antagonist).Nihon Rinsho. 2011 Nov;69 Suppl 9:408-11. [3]. Vaduganathan M, Gheorghiade M, Pang PS, Konstam MA, Zannad F, Swedberg K, Grinfeld L, Burnett JC Jr, Krasa HB, Zimmer C, Blair J, Ouyang J, Maggioni AP; EVEREST investigators.Efficacy of oral tolvaptan in acute heart failure patients with hypotension and renal impairment.J Cardiovasc Med (Hagerstown). 2012 Jul;13(7):415-22. [4]. Y Yamamura et al. OPC-41061, a Highly Potent Human Vasopressin V2-Receptor Antagonist: Pharmacological Profile and Aquaretic Effect by Single and Multiple Oral Dosing in Rats. J. Pharmacol. Exp. Ther. 1998, 287(3), 860-867. [5]. RW Schrier et al. Tolvaptan, a Selective Oral Vasopressin V2-Receptor Antagonist, for Hyponatremia. N Engl J Med 2006, 355, 2099-2112. |
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Frequently Asked Questions
What is the CAS number of Tolvaptan?
The CAS number of Tolvaptan is 150683-30-0.
What are the molecular formula and molecular weight of Tolvaptan?
Tolvaptan has molecular formula C26H25ClN2O3 and molecular weight 448.941 g/mol.
What are the upstream and downstream products of Tolvaptan?
For Tolvaptan, Upstream Products: N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-oxo-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide, 2-Methyl-4-nitrobenzoyl chloride, 7-chloro-1,2,3,4-tetrahydro-1-benzazepin-5-one; Downstream Products: N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-oxo-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Tolvaptan (CAS 150683-30-0)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1985187-7 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.