Helenalin

Also known as: (-)-Helenalin, Helenalin A, NSC 85236, 6α,8β-Dihydroxy-4-oxoambrosa-2,11(13)-dien-12-oic acid 12,8-lactone, Ambrosa-2,11(13)-dien-12-oic acid, 6α,8β-dihydroxy-4-oxo-, 12,8-lactone, (3aS,4S,4aR,7aR,8R,9aR)-3,3a,4,4a,7a,8,9,9a-Octahydro-4-hydroxy-4a,8-dimethyl-3-methyleneazuleno[6,5-b]furan-2,5-dione, Azuleno[6,5-b]furan-2,5-dione, 3,3a,4,4a,7a,8,9,9a-octahydro-4-hydroxy-4a,8-dimethyl-3-methylene-, (3aS,4S,4aR,7aR,8R,9aR)-

Helenalin (CAS 6754-13-8) is a compound in the Esters category listed in the Jingsj chemical database. It has the molecular formula C15H18O4 and a molecular weight of 262.30100 g/mol. Key properties include a melting point of 167-168ºC, a boiling point of 473ºC at 760 mmHg, a density of 1.25g/cm3 and a flash point of 179.9ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 6754-13-8
Jingsj CID: J-1984244-2
Molecular Formula: C₁₅H₁₈O₄
Molecular Weight: 262.30100 g/mol
Category: Esters
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	167-168ºC
Boiling Point	473ºC at 760 mmHg
Density	1.25g/cm3
Flash Point	179.9ºC
Exact Mass	262.12100
PSA	63.60000
LogP	1.24630
Refractive Index	1.565

Activity & Biological Data

Additional Information	[1]. Merrill JC, et al. Role of glutathione in the toxicity of the sesquiterpene lactones hymenoxon and helenalin. J Toxicol Environ Health. 1988;23(2):159-69. [2]. Lyss G, et al. The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65. J Biol Chem. 1998 Dec 11;273(50):33508-16. [3]. Fernandes KM, et al. Helenalin-mediated post-transcriptional regulation of p21(Cip1) inhibits 3T3-L1 preadipocyteproliferation. J Cell Biochem. 2008 Oct 15;105(3):913-21.

Additional Information

[1]. Merrill JC, et al. Role of glutathione in the toxicity of the sesquiterpene lactones hymenoxon and helenalin. J Toxicol Environ Health. 1988;23(2):159-69. [2]. Lyss G, et al. The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65. J Biol Chem. 1998 Dec 11;273(50):33508-16. [3]. Fernandes KM, et al. Helenalin-mediated post-transcriptional regulation of p21(Cip1) inhibits 3T3-L1 preadipocyteproliferation. J Cell Biochem. 2008 Oct 15;105(3):913-21.

Frequently Asked Questions

What is the CAS number of Helenalin?

The CAS number of Helenalin is 6754-13-8.

What are the molecular formula and molecular weight of Helenalin?

Helenalin has molecular formula C15H18O4 and molecular weight 262.30100 g/mol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Helenalin (CAS 6754-13-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1984244-2 (accessed 2026-11-06).

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