Zotiraciclib

Also known as: SB1317, TG-02, TG02, SB 1317, SB-1317, TG 02, Zotiraciclib free base, (E)-Zotiraciclib, (E/Z)-Zotiraciclib, CS-915, 14-methyl-20-oxa-5,7,14,27-tetraazatetracyclo[19.3.1.1²,⁶.1⁸,¹²]heptacosa-1(25),2,4,6(27),8,10,12(26),16,21,23-decaene, (16E)-14-methyl-20-oxa-5,7,14,27-tetraazatetracyclo[19.3.1.1²,⁶.1⁸,¹²]heptacosa-1(25),2(27),3,5,8(26),9,11,16,21,23-decaene

Zotiraciclib (CAS 937270-47-8) is a compound in the Aliphatic Hydrocarbons category listed in the Jingsj chemical database. It has the molecular formula C23H24N4O and a molecular weight of 372.463 g/mol. Key properties include a boiling point of 577.1±60.0 °C at 760 mmHg, a density of 1.1±0.1 g/cm3 and a flash point of 302.8±32.9 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 937270-47-8
Jingsj CID: J-1983382-4
Molecular Formula: C₂₃H₂₄N₄O
Molecular Weight: 372.463 g/mol
Category: Aliphatic Hydrocarbons
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	577.1±60.0 °C at 760 mmHg
Density	1.1±0.1 g/cm3
Flash Point	302.8±32.9 °C
Exact Mass	372.195007
PSA	50.28000
LogP	4.76
Vapor Pressure	0.0±1.6 mmHg at 25°C
Refractive Index	1.577
Storage Conditions	2-8℃

Activity & Biological Data

Target	CDK2:13 nM (IC50) JAK2:73 nM (IC50) FLT3:56 nM (IC50)
Additional Information	[1]. William AD, et al. Discovery of kinase spectrum selective macrocycle (16E)-14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene (SB1317/TG02), a potent inhibitor of cyclin dependent kina [2]. Pasha MK, et al. Preclinical metabolism and pharmacokinetics of SB1317 (TG02), a potent CDK/JAK2/FLT3 inhibitor. Drug Metab Lett. 2012 Mar;6(1):33-42.

Target

CDK2:13 nM (IC50) JAK2:73 nM (IC50) FLT3:56 nM (IC50)

Additional Information

[1]. William AD, et al. Discovery of kinase spectrum selective macrocycle (16E)-14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene (SB1317/TG02), a potent inhibitor of cyclin dependent kina [2]. Pasha MK, et al. Preclinical metabolism and pharmacokinetics of SB1317 (TG02), a potent CDK/JAK2/FLT3 inhibitor. Drug Metab Lett. 2012 Mar;6(1):33-42.

Frequently Asked Questions

What is the CAS number of Zotiraciclib?

The CAS number of Zotiraciclib is 937270-47-8.

What are the molecular formula and molecular weight of Zotiraciclib?

Zotiraciclib has molecular formula C23H24N4O and molecular weight 372.463 g/mol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Zotiraciclib (CAS 937270-47-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1983382-4 (accessed 2026-11-07).

Data for reference only; verify product details with suppliers before purchase.