AZD2461

Also known as: 4-[[4-fluoro-3-(4-methoxypiperidine-1-carbonyl)phenyl]methyl]-2H-phthalazin-1-one, 4-(4-fluoro-3-(4-methoxypiperidine-1-carbonyl)benzyl)phthalazin-1(2H)-one, 4-[4-fluoro-3-[(4-methoxypiperidin-1-yl)carbonyl]benzyl]phthalazin-1(2H)-one, 1(2H)-Phthalazinone, 4-[[4-fluoro-3-[(4-methoxy-1-piperidinyl)carbonyl]phenyl]methyl]-, AZD-2461, S7029, CS-1402

AZD2461 (CAS 1174043-16-3) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C22H22FN3O3 and a molecular weight of 395.427 g/mol. Key property: a density of 1.3±0.1 g/cm3. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 1174043-16-3
Jingsj CID: J-1982579-7
Molecular Formula: C₂₂H₂₂FN₃O₃
Molecular Weight: 395.427 g/mol
Category: Pharma Intermediates
Last updated: 8/21/2026

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Physicochemical Properties

Density	1.3±0.1 g/cm3
Exact Mass	395.164520
PSA	75.55000
LogP	0.53
Refractive Index	1.640
Storage Conditions	-20°C

Activity & Biological Data

Target	PARP2:2 nM (IC50) PARP1:5 nM (IC50) PARP3:200 nM (IC50)
Additional Information	[1]. Oplustil O'Connor L, et al. The PARP Inhibitor AZD2461 Provides Insights into the Role of PARP3 Inhibition for Both Synthetic Lethality and Tolerability with Chemotherapy in Preclinical Models. Cancer Res. 2016 Oct 15;76(20):6084-6094. Epub 2016 Aug 22. [2]. Węsierska-Gądek J, et al. Differential Potential of Pharmacological PARP Inhibitors for Inhibiting Cell Proliferation and Inducing Apoptosis in Human Breast Cancer Cells. J Cell Biochem. 2015 Dec;116(12):2824-39. [3]. Jaspers JE, et al. Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors. Cancer Discov. 2013 Jan;3(1):68-81.

Target

PARP2:2 nM (IC50) PARP1:5 nM (IC50) PARP3:200 nM (IC50)

Additional Information

[1]. Oplustil O'Connor L, et al. The PARP Inhibitor AZD2461 Provides Insights into the Role of PARP3 Inhibition for Both Synthetic Lethality and Tolerability with Chemotherapy in Preclinical Models. Cancer Res. 2016 Oct 15;76(20):6084-6094. Epub 2016 Aug 22. [2]. Węsierska-Gądek J, et al. Differential Potential of Pharmacological PARP Inhibitors for Inhibiting Cell Proliferation and Inducing Apoptosis in Human Breast Cancer Cells. J Cell Biochem. 2015 Dec;116(12):2824-39. [3]. Jaspers JE, et al. Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors. Cancer Discov. 2013 Jan;3(1):68-81.

Frequently Asked Questions

What is the CAS number of AZD2461?

The CAS number of AZD2461 is 1174043-16-3.

What are the molecular formula and molecular weight of AZD2461?

AZD2461 has molecular formula C22H22FN3O3 and molecular weight 395.427 g/mol.

What are the upstream and downstream products of AZD2461?

For AZD2461, Upstream Products: 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid, 4-Methoxypiperidine hydrochloride, 4-Methoxypiperidine.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "AZD2461 (CAS 1174043-16-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1982579-7 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.