Plinabulin
Also known as: (3Z,6Z)-3-Benzylidene-6-{[4-(2-methyl-2-propanyl)-1H-imidazol-5-yl]methylene}-2,5-piperazinedione, (3Z,6Z)-3-[(5-tert-Butyl-1H-imidazol-4-yl)methylene]-6-(phenylmethylene)-2,5-piperazinedione, NPI-2358, NPI 2358, NPI-2358 (Plinabulin), NPI-2358/KPU-2, tert-butyl-dehydrophenylahistin, Plinabulin [USAN:INN], Plinabulin(NPI-2358)
Plinabulin (CAS 714272-27-2) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C19H20N4O2 and a molecular weight of 336.388 g/mol. Key properties include a boiling point of 730.3±60.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 395.5±32.9 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 714272-27-2
- Jingsj CID
- J-1982387-1
- Molecular Formula
- C19H20N4O2
- Molecular Weight
- 336.388 g/mol
- Category
- Organic Compounds
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Boiling Point | 730.3±60.0 °C at 760 mmHg |
|---|---|
| Density | 1.3±0.1 g/cm3 |
| Flash Point | 395.5±32.9 °C |
| Exact Mass | 336.158630 |
| PSA | 94.92000 |
| LogP | 2.66 |
| Vapor Pressure | 0.0±2.4 mmHg at 25°C |
| Refractive Index | 1.657 |
Activity & Biological Data
| Additional Information | [1]. Nicholson B et al. NPI-2358 is a tubulin-depolymerizing agent: in-vitro evidence for activity as a tumor vascular-disrupting agent. Anticancer Drugs. 2006 Jan;17(1):25-31. [2]. Monica M. Mita et al. Phase 1 First-in-Human Trial of the Vascular Disrupting Agent Plinabulin (NPI-2358) in Patients with Solid Tumors or Lymphomas Clin Cancer Res December 1, 2010 16; 5892 [3]. Yakushiji F, Tanaka H, Muguruma K, Iwahashi T, Yamazaki Y, Hayashi Y.,Prodrug study of plinabulin using a click strategy focused on the effects of a replaceable water-solubilizing moiety.,Chem Pharm Bull (Tokyo). 2012;60(7):877-81. [4]. Yamazaki Y, Sumikura M, Masuda Y, Hayashi Y, Yasui H, Kiso Y, Chinen T, Usui T, Yakushiji F, Potts B, Neuteboom S, Palladino M, Lloyd GK, Hayashi Y.,Synthesis and structure-activity relationships of benzophenone-bearing diketopiperazine-type anti-microtubule agents.,Bioorg Med Chem. 2012 Jul 15;20(14):4279-89. Epub 2012 Jun 4. [5]. Bertelsen LB, Shen YY, Nielsen T, St?dkilde-J?rgensen H, Lloyd GK, Siemann DW, Horsman MR.,Vascular effects of plinabulin (NPI-2358) and the influence on tumour response when given alone or combined with radiation.Int J Radiat Biol. 2011 Nov;87(11):1126-34. |
|---|
Frequently Asked Questions
What is the CAS number of Plinabulin?
The CAS number of Plinabulin is 714272-27-2.
What are the molecular formula and molecular weight of Plinabulin?
Plinabulin has molecular formula C19H20N4O2 and molecular weight 336.388 g/mol.
What are the upstream and downstream products of Plinabulin?
For Plinabulin, Upstream Products: Benzaldehyde, 5-(tert-Butyl)-1H-imidazole-4-carbaldehyde, Ethyl 4,4-dimethyl-3-oxovalerate.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Plinabulin (CAS 714272-27-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1982387-1 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.