Rosuvastatin

Also known as: Crestor, ZD 4522, X-Plended, (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid, 7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-(methyl-methylsulfonyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid, Rosuvastatin Acid, S-4522

Rosuvastatin (CAS 287714-41-4) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C22H28FN3O6S and a molecular weight of 481.54 g/mol. Key properties include a boiling point of 745.6ºC at 760 mmHg, a density of 1.368 g/cm3 and a flash point of 404.7ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 287714-41-4
Jingsj CID: J-1981667-2
Molecular Formula: C₂₂H₂₈FN₃O₆S
Molecular Weight: 481.54 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	745.6ºC at 760 mmHg
Density	1.368 g/cm3
Flash Point	404.7ºC
PSA	152.13000
LogP	2.14780
Vapor Pressure	2.38E-23mmHg at 25°C
Refractive Index	1.597
Storage Conditions	2-8°C

Activity & Biological Data

Additional Information	[1]. Watanabe, M., et al., Synthesis and biological activity of methanesulfonamide pyrimidine- and N-methanesulfonyl pyrrole-substituted 3,5-dihydroxy-6-heptenoates, a novel series of HMG-CoA reductase inhibitors. Bioorg Med Chem, 1997. 5(2): p. 437-44. [2]. Schneck, D.W., et al., The effect of gemfibrozil on the pharmacokinetics of rosuvastatin. Clin Pharmacol Ther, 2004. 75(5): p. 455-63. [3]. Kim, Y.S., et al., Rosuvastatin suppresses the inflammatory responses through inhibition of c-Jun N-terminal kinase and Nuclear Factor-kappaB in endothelial cells. J Cardiovasc Pharmacol, 2007. 49(6): p. 376-83. [4]. Carswell, C.I., G.L. Plosker, and B. Jarvis, Rosuvastatin. Drugs, 2002. 62(14): p. 2075-85; discussion 2086-7. [5]. Stalker, T.J., A.M. Lefer, and R. Scalia, A new HMG-CoA reductase inhibitor, rosuvastatin, exerts anti-inflammatory effects on the microvascular endothelium: the role of mevalonic acid. Br J Pharmacol, 2001. 133(3): p. 406-12.

Additional Information

[1]. Watanabe, M., et al., Synthesis and biological activity of methanesulfonamide pyrimidine- and N-methanesulfonyl pyrrole-substituted 3,5-dihydroxy-6-heptenoates, a novel series of HMG-CoA reductase inhibitors. Bioorg Med Chem, 1997. 5(2): p. 437-44. [2]. Schneck, D.W., et al., The effect of gemfibrozil on the pharmacokinetics of rosuvastatin. Clin Pharmacol Ther, 2004. 75(5): p. 455-63. [3]. Kim, Y.S., et al., Rosuvastatin suppresses the inflammatory responses through inhibition of c-Jun N-terminal kinase and Nuclear Factor-kappaB in endothelial cells. J Cardiovasc Pharmacol, 2007. 49(6): p. 376-83. [4]. Carswell, C.I., G.L. Plosker, and B. Jarvis, Rosuvastatin. Drugs, 2002. 62(14): p. 2075-85; discussion 2086-7. [5]. Stalker, T.J., A.M. Lefer, and R. Scalia, A new HMG-CoA reductase inhibitor, rosuvastatin, exerts anti-inflammatory effects on the microvascular endothelium: the role of mevalonic acid. Br J Pharmacol, 2001. 133(3): p. 406-12.

Frequently Asked Questions

What is the CAS number of Rosuvastatin?

The CAS number of Rosuvastatin is 287714-41-4.

What are the molecular formula and molecular weight of Rosuvastatin?

Rosuvastatin has molecular formula C22H28FN3O6S and molecular weight 481.54 g/mol.

What are the upstream and downstream products of Rosuvastatin?

For Rosuvastatin, Upstream Products: 5-Oxorosuvastatin Methyl Ester, tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate, Rosuvastatin methyl ester; Downstream Products: Rosuvastatin-5S-lactone.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Rosuvastatin (CAS 287714-41-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1981667-2 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.