Ramelteon

Also known as: (S)-N-[2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethyl]propionamide, N-[2-[(8S)-2,6,7,8-tetrahydro-1H-cyclopenta[e][1]benzofuran-8-yl]ethyl]propanamide, Rozerem, TAK-375, UNII-901AS54I69, [14C]-Ramelteon

Ramelteon (CAS 196597-26-9) is a compound in the Organic Bases category listed in the Jingsj chemical database. It has the molecular formula C16H21NO2 and a molecular weight of 259.343 g/mol. Key properties include a melting point of 113-115ºC, a boiling point of 455.3±24.0 °C at 760 mmHg, a density of 1.1±0.1 g/cm3 and a flash point of 229.2±22.9 °C. It is classified under GHS with signal word Danger and hazard statements H225 — Highly flammable liquid and vapour, H302 — Harmful if swallowed and H312 — Harmful in contact with skin. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 196597-26-9
Jingsj CID: J-1981635-4
Molecular Formula: C₁₆H₂₁NO₂
Molecular Weight: 259.343 g/mol
Category: Organic Bases
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	113-115ºC
Boiling Point	455.3±24.0 °C at 760 mmHg
Density	1.1±0.1 g/cm3
Flash Point	229.2±22.9 °C
Exact Mass	259.157227
PSA	38.33000
LogP	2.57
Vapor Pressure	0.0±1.1 mmHg at 25°C
Refractive Index	1.556
Storage Conditions	-20°C Freezer

GHS Safety & Compliance

Flammable / IrritantSignal word: Danger

H225 — Highly flammable liquid and vapour
H302 — Harmful if swallowed
H312 — Harmful in contact with skin
H332 — Harmful if inhaled
H319 — Causes serious eye irritation

Activity & Biological Data

Target	IC50: 14 pM (melatonin1), 112 pM (melatonin2)[1]
Additional Information	[1]. Kato K, et al. Neurochemical properties of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist. Neuropharmacology. 2005 Feb;48(2):301-10. [2]. Miyamoto M, et al. The sleep-promoting action of ramelteon (TAK-375) in freely moving cats. Sleep. 2004 Nov 1;27(7):1319-25. [3]. Kuriyama A, et al. Ramelteon for the treatment of insomnia in adults: a systematic review and meta-analysis. Sleep Med. 2014 Apr;15(4):385-92. [4]. Fisher SP, et al. Acute sleep-promoting action of the melatonin agonist, ramelteon, in the rat. J Pineal Res. 2008 Sep;45(2):125-32.

Target

IC50: 14 pM (melatonin1), 112 pM (melatonin2)[1]

Additional Information

[1]. Kato K, et al. Neurochemical properties of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist. Neuropharmacology. 2005 Feb;48(2):301-10. [2]. Miyamoto M, et al. The sleep-promoting action of ramelteon (TAK-375) in freely moving cats. Sleep. 2004 Nov 1;27(7):1319-25. [3]. Kuriyama A, et al. Ramelteon for the treatment of insomnia in adults: a systematic review and meta-analysis. Sleep Med. 2014 Apr;15(4):385-92. [4]. Fisher SP, et al. Acute sleep-promoting action of the melatonin agonist, ramelteon, in the rat. J Pineal Res. 2008 Sep;45(2):125-32.

Frequently Asked Questions

What is the CAS number of Ramelteon?

The CAS number of Ramelteon is 196597-26-9.

What are the molecular formula and molecular weight of Ramelteon?

Ramelteon has molecular formula C16H21NO2 and molecular weight 259.343 g/mol.

Is Ramelteon hazardous?

Ramelteon has GHS signal word Danger and hazard statements H225 — Highly flammable liquid and vapour; H302 — Harmful if swallowed; H312 — Harmful in contact with skin.

What are the upstream and downstream products of Ramelteon?

For Ramelteon, Upstream Products: (S)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)acetonitrile, Propionic anhydride, 6-Methoxy-1-indanone.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Ramelteon (CAS 196597-26-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1981635-4 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.