Brivanib

Also known as: BMS-540215, Brivanib (BMS-540215), 1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol, (2R)-1-[4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]propanol

Brivanib (CAS 649735-46-6) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C19H19FN4O3 and a molecular weight of 370.378 g/mol. Key property: a density of 1.4±0.1 g/cm3. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 649735-46-6
Jingsj CID: J-1980241-6
Molecular Formula: C₁₉H₁₉FN₄O₃
Molecular Weight: 370.378 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Density	1.4±0.1 g/cm3
Exact Mass	370.144104
PSA	84.67000
LogP	2.48
Refractive Index	1.661

Activity & Biological Data

Target	VEGFR2:25 nM (IC50)
Additional Information	[1]. Bhide RS, et al. Discovery and preclinical studies of (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5- methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan- 2-ol (BMS-540215), an in vivo active potent VEGFR-2 inhibitor. J Med Chem, 2006, 49 (7), 2143-2146. [2]. Huynh H, et al. Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma. Clin Cancer Res, 2008, [3]. Nakamura I, et al. Correction: Brivanib Attenuates Hepatic Fibrosis In Vivo and Stellate Cell Activation In Vitro by Inhibition of FGF, VEGF and PDGF Signaling. PLoS One. 2015 Nov 3;10(11):e0142355.

Target

VEGFR2:25 nM (IC50)

Additional Information

[1]. Bhide RS, et al. Discovery and preclinical studies of (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5- methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan- 2-ol (BMS-540215), an in vivo active potent VEGFR-2 inhibitor. J Med Chem, 2006, 49 (7), 2143-2146. [2]. Huynh H, et al. Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma. Clin Cancer Res, 2008, [3]. Nakamura I, et al. Correction: Brivanib Attenuates Hepatic Fibrosis In Vivo and Stellate Cell Activation In Vitro by Inhibition of FGF, VEGF and PDGF Signaling. PLoS One. 2015 Nov 3;10(11):e0142355.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Brivanib?

The CAS number of Brivanib is 649735-46-6.

What are the molecular formula and molecular weight of Brivanib?

Brivanib has molecular formula C19H19FN4O3 and molecular weight 370.378 g/mol.

What are the upstream and downstream products of Brivanib?

For Brivanib, Upstream Products: 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-ol, (R)-(+)-Propylene oxide, 4-Fluoro-2-methyl-1H-indol-5-ol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Brivanib (CAS 649735-46-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1980241-6 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.