Lonafarnib
Also known as: SCH 66336, Sarasar, SCH-66336, SCH66336, 1-Piperidinecarboxamide, 4-[2-[4-[(11R)-3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-, 4-[2-[4-[(11R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide, (R)-4-[2-[4-[3,10-dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide, Lonafarnib [USAN], [14C]-Lonafarnib
Lonafarnib (CAS 193275-84-2) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C27H31Br2ClN4O2 and a molecular weight of 638.822 g/mol. Key properties include a melting point of 214.5-215.9° (monohydrate); mp 222-223°, a boiling point of 710.4±70.0 °C at 760 mmHg, a density of 1.5±0.1 g/cm3 and a flash point of 383.5±35.7 °C. It is classified under GHS with signal word Warning and hazard statements H315 — Causes skin irritation, H319 — Causes serious eye irritation and H335 — May cause respiratory irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 193275-84-2
- Jingsj CID
- J-1980217-6
- Molecular Formula
- C27H31Br2ClN4O2
- Molecular Weight
- 638.822 g/mol
- Category
- Organic Compounds
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 214.5-215.9° (monohydrate); mp 222-223° |
|---|---|
| Boiling Point | 710.4±70.0 °C at 760 mmHg |
| Density | 1.5±0.1 g/cm3 |
| Flash Point | 383.5±35.7 °C |
| Exact Mass | 636.050232 |
| PSA | 79.53000 |
| LogP | 5.03 |
| Vapor Pressure | 0.0±2.3 mmHg at 25°C |
| Refractive Index | 1.630 |
| Storage Conditions | -20℃ |
GHS Safety & Compliance
- H315 — Causes skin irritation
- H319 — Causes serious eye irritation
- H335 — May cause respiratory irritation
Activity & Biological Data
| Target | IC50: 1.9 nM (H-ras), 5.2 nM (K-ras), 2.8 nM (N-ras)[1] |
|---|---|
| Additional Information | [1]. Liu M, et al. Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice. Cancer Res. 1998 Nov 1;58(21):4947-56. [2]. Chaponis D, et al. Lonafarnib (SCH66336) improves the activity of temozolomide and radiation for orthotopic malignant gliomas. J Neurooncol. 2011 Aug;104(1):179-89. |
Frequently Asked Questions
What is the CAS number of Lonafarnib?
The CAS number of Lonafarnib is 193275-84-2.
What are the molecular formula and molecular weight of Lonafarnib?
Lonafarnib has molecular formula C27H31Br2ClN4O2 and molecular weight 638.822 g/mol.
Is Lonafarnib hazardous?
Lonafarnib has GHS signal word Warning and hazard statements H315 — Causes skin irritation; H319 — Causes serious eye irritation; H335 — May cause respiratory irritation.
What are the upstream and downstream products of Lonafarnib?
For Lonafarnib, Upstream Products: Trimethylsilyl isocyanate, Urea, 1-(tert-Butoxycarbonyl)-4-piperidylacetic acid.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Lonafarnib (CAS 193275-84-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1980217-6 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.