Efavirenz

Also known as: Sustiva, Stocrin, DMP 266, (4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one, (4S)-6-Chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one, (S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one

Efavirenz (CAS 154598-52-4) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C14H9ClF3NO2 and a molecular weight of 315.675 g/mol. Key properties include a melting point of 139-141ºC, a boiling point of 422.7±55.0 °C at 760 mmHg, a density of 1.5±0.1 g/cm3 and a flash point of 209.4±31.5 °C. It is classified under GHS with signal word Warning and hazard statements H410 — Very toxic to aquatic life with long lasting effects. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 154598-52-4
Jingsj CID: J-1980174-2
Molecular Formula: C₁₄H₉ClF₃NO₂
Molecular Weight: 315.675 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	139-141ºC
Boiling Point	422.7±55.0 °C at 760 mmHg
Density	1.5±0.1 g/cm3
Flash Point	209.4±31.5 °C
Exact Mass	315.027405
PSA	38.33000
LogP	3.72
Vapor Pressure	0.0±1.1 mmHg at 25°C
Refractive Index	1.582

GHS Safety & Compliance

Environmental HazardSignal word: Warning

H410 — Very toxic to aquatic life with long lasting effects

Activity & Biological Data

Target	Ki: 2.93 nM (HIV-1 RT)[1]
Additional Information	[1]. Young SD, et al. L-743, 726 (DMP-266): a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase. Antimicrob Agents Chemother. 1995 Dec;39(12):2602-5. [2]. Held DM, et al. Differential susceptibility of HIV-1 reverse transcriptase to inhibition by RNA aptamers in enzymatic reactions monitoring specific steps during genome replication. J Biol Chem. 2006 Sep 1;281(35):25712-22. [3]. Grobler JA, et al. HIV-1 reverse transcriptase plus-strand initiation exhibits preferential sensitivity to non-nucleoside reverse transcriptase inhibitors in vitro. J Biol Chem. 2007 Mar 16;282(11):8005-10.

Target

Ki: 2.93 nM (HIV-1 RT)[1]

Additional Information

[1]. Young SD, et al. L-743, 726 (DMP-266): a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase. Antimicrob Agents Chemother. 1995 Dec;39(12):2602-5. [2]. Held DM, et al. Differential susceptibility of HIV-1 reverse transcriptase to inhibition by RNA aptamers in enzymatic reactions monitoring specific steps during genome replication. J Biol Chem. 2006 Sep 1;281(35):25712-22. [3]. Grobler JA, et al. HIV-1 reverse transcriptase plus-strand initiation exhibits preferential sensitivity to non-nucleoside reverse transcriptase inhibitors in vitro. J Biol Chem. 2007 Mar 16;282(11):8005-10.

Customs & Trade Information

HS Code	2942000000

Frequently Asked Questions

What is the CAS number of Efavirenz?

The CAS number of Efavirenz is 154598-52-4.

What are the molecular formula and molecular weight of Efavirenz?

Efavirenz has molecular formula C14H9ClF3NO2 and molecular weight 315.675 g/mol.

Is Efavirenz hazardous?

Efavirenz has GHS signal word Warning and hazard statements H410 — Very toxic to aquatic life with long lasting effects.

What are the upstream and downstream products of Efavirenz?

For Efavirenz, Upstream Products: Bis(trichloromethyl) carbonate, (S)-1-(2-Amino-5-chlorophenyl)-1-(trifluoromethyl)-3-cyclopropyl-2-propyn-1-ol, Diphosgene.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Efavirenz (CAS 154598-52-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1980174-2 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.