Istradefylline

Also known as: KW-6002, (E)-8-(3,4-Dimethoxystyryl)-1,3-diethyl-7-methyl-1H-purine-2,6(3H,7H)-dione, (E)-8-(3,4-Dimethoxystyryl)-1,3-diethyl-7-methylxanthine, 8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methylpurine-2,6-dione, CS-285, 2GZ0LIK7T4

Istradefylline (CAS 155270-99-8) is a compound in the Organic Bases category listed in the Jingsj chemical database. It has the molecular formula C20H24N4O4 and a molecular weight of 384.429 g/mol. Key properties include a boiling point of 601.0±65.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 317.3±34.3 °C. It is classified under GHS with signal word Danger and hazard statements H301 — Toxic if swallowed. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 155270-99-8
Jingsj CID: J-1979168-5
Molecular Formula: C₂₀H₂₄N₄O₄
Molecular Weight: 384.429 g/mol
Category: Organic Bases
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	601.0±65.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	317.3±34.3 °C
Exact Mass	384.179749
PSA	80.28000
LogP	2.84
Appearance	white to beige
Vapor Pressure	0.0±1.7 mmHg at 25°C
Refractive Index	1.598
Storage Conditions	2-8°C
Additional Property	DMSO: soluble5mg/mL (clear solution)

GHS Safety & Compliance

Acute ToxicitySignal word: Danger

H301 — Toxic if swallowed

Activity & Biological Data

Target	Ki: 2.2 nM (adenosine A2A receptor)
Additional Information	[1]. Chen JF, et al. Neuroprotection by caffeine and A(2A) adenosine receptor inactivation in a model of Parkinson's disease. J Neurosci. 2001 May 15;21(10):RC143. [2]. Shiozaki S, et al. Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP. Psychopharmacology (Berl). 1999 Nov;147(1):90-5. [3]. Kanda T, et al. Combined use of the adenosine A(2A) antagonist KW-6002 with L-DOPA or with selective D1 or D2 dopamine agonists increases antiparkinsonian activity but not dyskinesia in MPTP-treated monkeys. Exp Neurol. 2000 Apr;162(2):321-7. [4]. Brambilla R, et al. Blockade of A2A adenosine receptors prevents basic fibroblast growth factor-induced reactive astrogliosis in rat striatal primary astrocytes. Glia. 2003 Aug;43(2):190-4. [5]. Mihara T, et al. Pharmacological characterization of a novel, potent adenosine A1 and A2A receptor dual antagonist, 5-[5-amino-3-(4-fluorophenyl)pyrazin-2-yl]-1-isopropylpyridine-2(1H)-one (ASP5854), in models of Parkinson's disease and cognition. J Pharm

Target

Ki: 2.2 nM (adenosine A2A receptor)

Additional Information

[1]. Chen JF, et al. Neuroprotection by caffeine and A(2A) adenosine receptor inactivation in a model of Parkinson's disease. J Neurosci. 2001 May 15;21(10):RC143. [2]. Shiozaki S, et al. Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP. Psychopharmacology (Berl). 1999 Nov;147(1):90-5. [3]. Kanda T, et al. Combined use of the adenosine A(2A) antagonist KW-6002 with L-DOPA or with selective D1 or D2 dopamine agonists increases antiparkinsonian activity but not dyskinesia in MPTP-treated monkeys. Exp Neurol. 2000 Apr;162(2):321-7. [4]. Brambilla R, et al. Blockade of A2A adenosine receptors prevents basic fibroblast growth factor-induced reactive astrogliosis in rat striatal primary astrocytes. Glia. 2003 Aug;43(2):190-4. [5]. Mihara T, et al. Pharmacological characterization of a novel, potent adenosine A1 and A2A receptor dual antagonist, 5-[5-amino-3-(4-fluorophenyl)pyrazin-2-yl]-1-isopropylpyridine-2(1H)-one (ASP5854), in models of Parkinson's disease and cognition. J Pharm

Frequently Asked Questions

What is the CAS number of Istradefylline?

The CAS number of Istradefylline is 155270-99-8.

What are the molecular formula and molecular weight of Istradefylline?

Istradefylline has molecular formula C20H24N4O4 and molecular weight 384.429 g/mol.

Is Istradefylline hazardous?

Istradefylline has GHS signal word Danger and hazard statements H301 — Toxic if swallowed.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Istradefylline (CAS 155270-99-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1979168-5 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.