Etravirine

Also known as: TMC-125, TMC125, Intelence, R165335, 4-[[6-amino-5-bromo-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-dimethylbenzonitrile, 4-({6-amino-5-bromo-2-[(4-cyanophenyl)amino]pyrimidin-4-yl}oxy)-3,5-dimethylbenzonitrile, 4-((6-amino-5-bromo-2-((4-cyanophenyl)amino)pyrimidin-4-yl)oxy)-3,5-dimethylbenzonitrile

Etravirine (CAS 269055-15-4) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C20H15BrN6O and a molecular weight of 435.277 g/mol. Key properties include a melting point of 265ºC (dec.), a boiling point of 637.4±65.0 °C at 760 mmHg, a density of 1.6±0.1 g/cm3 and a flash point of 339.3±34.3 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 269055-15-4
Jingsj CID: J-1979131-2
Molecular Formula: C₂₀H₁₅BrN₆O
Molecular Weight: 435.277 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	265ºC (dec.)
Boiling Point	637.4±65.0 °C at 760 mmHg
Density	1.6±0.1 g/cm3
Flash Point	339.3±34.3 °C
Exact Mass	434.049072
PSA	120.64000
LogP	4.19
Vapor Pressure	0.0±1.9 mmHg at 25°C
Refractive Index	1.703
Storage Conditions	-20°C Freezer

Activity & Biological Data

Additional Information	[1]. Andries, K., et al. TMC125, a novel next-generation nonnucleoside reverse transcriptase inhibitor active against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus type 1. Antimicrob Agents Chemother, 2004. 48(12): p. 468 [2]. Lazzarin, A., et al. Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-2: 24-week results from a randomised, double-blind, placebo-controlled trial. Lancet, 2007. 370(9581): p. 39-48.

Additional Information

[1]. Andries, K., et al. TMC125, a novel next-generation nonnucleoside reverse transcriptase inhibitor active against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus type 1. Antimicrob Agents Chemother, 2004. 48(12): p. 468 [2]. Lazzarin, A., et al. Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-2: 24-week results from a randomised, double-blind, placebo-controlled trial. Lancet, 2007. 370(9581): p. 39-48.

Frequently Asked Questions

What is the CAS number of Etravirine?

The CAS number of Etravirine is 269055-15-4.

What are the molecular formula and molecular weight of Etravirine?

Etravirine has molecular formula C20H15BrN6O and molecular weight 435.277 g/mol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Etravirine (CAS 269055-15-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1979131-2 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.