SGI-1776 free base

Also known as: Imidazo[1,2-b]pyridazin-6-amine, N-[(1-methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-, N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine, N-[(1-Methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-imidazo[1,2-b]pyridazin-6-amine, N-[(1-Methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-imidazo[1,2-b]pyridazin-6-amine SGI-1776, N-[(1-Methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amine, N-[(1-methylpiperidin-4-yl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amine, SGI 1776, SGI-1776 FREE BASE, SGI-1776 free base N-[(1-Methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-imidazo[1,2-b]pyridazin-6-amine, SGI-1776, >=98%, SGI-1776,SGI1776, SGI1776

SGI-1776 free base (CAS 1025065-69-3) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C20H22F3N5O and a molecular weight of 405.417 g/mol. Key property: a density of 1.4±0.1 g/cm3. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 1025065-69-3
Jingsj CID: J-1978799-6
Molecular Formula: C₂₀H₂₂F₃N₅O
Molecular Weight: 405.417 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Density	1.4±0.1 g/cm3
Exact Mass	405.177643
PSA	57.92000
LogP	3.36
Refractive Index	1.613

Activity & Biological Data

Target	Ki: 7 nM (Pim-1), 363 nM (Pim-2), 69 nM (Pim-3)[4]
Additional Information	[1]. Hou X, et al. Biochemical changes of salivary gland adenoid cystic carcinoma cells induced by SGI-1776. Exp Cell Res. 2017 Mar 15;352(2):403-411. [2]. Park YK, et al. The novel anti-adipogenic effect and mechanisms of action of SGI-1776, a Pim-specific inhibitor, in 3T3-L1 adipocytes. Int J Mol Med. 2016 Jan;37(1):157-64 [3]. Xie J, et al. SGI-1776, an imidazo pyridazine compound, inhibits the proliferation of ovarian cancer cells by inactivating Pim-1. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2014 Jul;39(7):649-57 [4]. Chen LS, et al. Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia. Blood, 2011, 118(3), 693-702.

Target

Ki: 7 nM (Pim-1), 363 nM (Pim-2), 69 nM (Pim-3)[4]

Additional Information

[1]. Hou X, et al. Biochemical changes of salivary gland adenoid cystic carcinoma cells induced by SGI-1776. Exp Cell Res. 2017 Mar 15;352(2):403-411. [2]. Park YK, et al. The novel anti-adipogenic effect and mechanisms of action of SGI-1776, a Pim-specific inhibitor, in 3T3-L1 adipocytes. Int J Mol Med. 2016 Jan;37(1):157-64 [3]. Xie J, et al. SGI-1776, an imidazo pyridazine compound, inhibits the proliferation of ovarian cancer cells by inactivating Pim-1. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2014 Jul;39(7):649-57 [4]. Chen LS, et al. Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia. Blood, 2011, 118(3), 693-702.

Frequently Asked Questions

What is the CAS number of SGI-1776 free base?

The CAS number of SGI-1776 free base is 1025065-69-3.

What are the molecular formula and molecular weight of SGI-1776 free base?

SGI-1776 free base has molecular formula C20H22F3N5O and molecular weight 405.417 g/mol.

What are the upstream and downstream products of SGI-1776 free base?

For SGI-1776 free base, Upstream Products: 1-Methyl-4-(aminomethyl)piperidine.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "SGI-1776 free base (CAS 1025065-69-3)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1978799-6 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.