2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)benzene-1,3-dicarbonitrile

Also known as: MF63, MF 63, MF-63, CS-0508, CS-2773, QCR-11, 1,3-Benzenedicarbonitrile, 2-(9-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-, 2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)isophthalonitrile, 2-(6-chloro-3H-phenanthro[9,10-d]imidazol-2-yl)benzene-1,3-dicarbonitrile, 2-(9-Chloro-1H-phenanthro[9,10-d]imidazol-2-yl)benzene-1,3-dicarbonitrile

2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)benzene-1,3-dicarbonitrile (CAS 892549-43-8) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C23H11ClN4 and a molecular weight of 378.81300 g/mol. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 892549-43-8
Jingsj CID: J-1978573-0
Molecular Formula: C₂₃H₁₁ClN₄
Molecular Weight: 378.81300 g/mol
Category: Pharma Intermediates
Last updated: 8/21/2026

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Physicochemical Properties

Exact Mass	378.06700
PSA	76.26000
LogP	5.93306
Storage Conditions	2-8℃

Activity & Biological Data

Additional Information	[1]. Xu D et al. MF63 [2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation. J Pharmacol Exp Ther. 2008 Sep;326(3):754-6 [2]. Coté B et al. Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6816-20. [3]. Baragatti B, Coceani F.,Dual, constrictor-to-dilator, response of the mouse ductus arteriosus to the microsomal prostaglandin E synthase-1 inhibitor, 2-(6-chloro-1H-phenanthro[9,10d]imidazole- 2-yl)isophthalonitrile.,Neonatology. 2011;100(2):139-46. Epub [4]. Giroux A, et al. Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors.,Bioorg Med Chem Lett. 2009 Oct 15;19(20):5837-41. Epub 2009 Aug 28. [5]. Xu D, L,et al. MF63 [2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation.,J Pharmacol Exp Ther. 2008 Sep;326(3):75

Additional Information

[1]. Xu D et al. MF63 [2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation. J Pharmacol Exp Ther. 2008 Sep;326(3):754-6 [2]. Coté B et al. Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6816-20. [3]. Baragatti B, Coceani F.,Dual, constrictor-to-dilator, response of the mouse ductus arteriosus to the microsomal prostaglandin E synthase-1 inhibitor, 2-(6-chloro-1H-phenanthro[9,10d]imidazole- 2-yl)isophthalonitrile.,Neonatology. 2011;100(2):139-46. Epub [4]. Giroux A, et al. Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors.,Bioorg Med Chem Lett. 2009 Oct 15;19(20):5837-41. Epub 2009 Aug 28. [5]. Xu D, L,et al. MF63 [2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation.,J Pharmacol Exp Ther. 2008 Sep;326(3):75

Frequently Asked Questions

What is the CAS number of 2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)benzene-1,3-dicarbonitrile?

The CAS number of 2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)benzene-1,3-dicarbonitrile is 892549-43-8.

What are the molecular formula and molecular weight of 2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)benzene-1,3-dicarbonitrile?

2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)benzene-1,3-dicarbonitrile has molecular formula C23H11ClN4 and molecular weight 378.81300 g/mol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)benzene-1,3-dicarbonitrile (CAS 892549-43-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1978573-0 (accessed 2026-11-06).

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