Taladegib

Also known as: LY2940680, LY-2940680, 4-fluoro-N-methyl-N-(1-(4-(1-methyl-1H-pyrazol-5-yl)phthalazin-1-yl)piperidin-4-yl)-2-(trifluoromethyl)benzamide, 4-fluoro-N-methyl-N-[1-[4-(2-methylpyrazol-3-yl)phthalazin-1-yl]piperidin-4-yl]-2-(trifluoromethyl)benzamide, Benzamide, 4-fluoro-N-methyl-N-[1-[4-(1-methyl-1H-pyrazol-5-yl)-1-phthalazinyl]-4-piperidinyl]-2-(trifluoromethyl)-

Taladegib (CAS 1258861-20-9) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C26H24F4N6O and a molecular weight of 512.502 g/mol. Key properties include a boiling point of 703.5±60.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 379.3±32.9 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 1258861-20-9
Jingsj CID: J-1978488-4
Molecular Formula: C₂₆H₂₄F₄N₆O
Molecular Weight: 512.502 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

Request MSDS / TDS

No offers for this compound yet.

Request a quote

Physicochemical Properties

Boiling Point	703.5±60.0 °C at 760 mmHg
Density	1.4±0.1 g/cm3
Flash Point	379.3±32.9 °C
Exact Mass	512.194763
PSA	67.15000
LogP	2.70
Vapor Pressure	0.0±2.2 mmHg at 25°C
Refractive Index	1.634
Storage Conditions	-20°C

Activity & Biological Data

Target	Smo[1]
Additional Information	[1]. Fraveto A, et al, Sensitivity of Human Intrahepatic Cholangiocarcinoma Subtypes to Chemotherapeutics and Molecular Targeted Agents: A Study on Primary Cell Cultures. PLoS One. 2015 Nov 16;10(11):e0142124. [2]. Hoch L, et al. MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor. FASEB J. 2015 May;29(5):1817-29. [3]. Ma W, et al. Reduced Smoothened level rescued Aβ-induced memory deficits and neuronal inflammation in animal models of Alzheimer's disease. J Genet Genomics. 2018 May 20;45(5):237-246.

Target

Smo[1]

Additional Information

[1]. Fraveto A, et al, Sensitivity of Human Intrahepatic Cholangiocarcinoma Subtypes to Chemotherapeutics and Molecular Targeted Agents: A Study on Primary Cell Cultures. PLoS One. 2015 Nov 16;10(11):e0142124. [2]. Hoch L, et al. MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor. FASEB J. 2015 May;29(5):1817-29. [3]. Ma W, et al. Reduced Smoothened level rescued Aβ-induced memory deficits and neuronal inflammation in animal models of Alzheimer's disease. J Genet Genomics. 2018 May 20;45(5):237-246.

Frequently Asked Questions

What is the CAS number of Taladegib?

The CAS number of Taladegib is 1258861-20-9.

What are the molecular formula and molecular weight of Taladegib?

Taladegib has molecular formula C26H24F4N6O and molecular weight 512.502 g/mol.

What are the upstream and downstream products of Taladegib?

For Taladegib, Upstream Products: 4-Fluoro-2-(trifluoromethyl)benzoyl chloride.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Taladegib (CAS 1258861-20-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1978488-4 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.