3-(azepan-1-ylsulfonyl)-N-(3-bromophenyl)benzamide

Also known as: AK-7, AK7, AK 7, 3-(1-azepanylsulfonyl)-N-(3-bromophenyl)benzamide, N-(3-Bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-benzamide, Benzamide, N-(3-bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-, SIRT2 Inhibitor II, SIRT2 Inhibitor, AK-7, UNII-308B6B695N

3-(azepan-1-ylsulfonyl)-N-(3-bromophenyl)benzamide (CAS 420831-40-9) is a compound in the Organic Bases category listed in the Jingsj chemical database. It has the molecular formula C19H21BrN2O3S and a molecular weight of 437.351 g/mol. Key property: a density of 1.5±0.1 g/cm3. It is classified under GHS with signal word Warning and hazard statements H319 — Causes serious eye irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 420831-40-9
Jingsj CID: J-1977831-6
Molecular Formula: C₁₉H₂₁BrN₂O₃S
Molecular Weight: 437.351 g/mol
Category: Organic Bases
Last updated: 8/21/2026

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Physicochemical Properties

Density	1.5±0.1 g/cm3
Exact Mass	436.045624
PSA	74.86000
LogP	4.93
Refractive Index	1.631
Storage Conditions	2-8℃

GHS Safety & Compliance

IrritantSignal word: Warning

H319 — Causes serious eye irritation

Activity & Biological Data

Target	SIRT2:15.5 μM (IC50)
Additional Information	[1]. Taylor DM, et al. A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase. ACS Chem Biol. 2011 Jun 17;6(6):540-6. [2]. Chopra V, et al. The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington's disease mouse models. Cell Rep. 2012 Dec 27;2(6):1492-7. [3]. Szego EM, et al. Sirtuin 2 enhances dopaminergic differentiation via the AKT/GSK-3β/β-catenin pathway. Neurobiol Aging. 2017 Aug;56:7-16.

Target

SIRT2:15.5 μM (IC50)

Additional Information

[1]. Taylor DM, et al. A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase. ACS Chem Biol. 2011 Jun 17;6(6):540-6. [2]. Chopra V, et al. The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington's disease mouse models. Cell Rep. 2012 Dec 27;2(6):1492-7. [3]. Szego EM, et al. Sirtuin 2 enhances dopaminergic differentiation via the AKT/GSK-3β/β-catenin pathway. Neurobiol Aging. 2017 Aug;56:7-16.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of 3-(azepan-1-ylsulfonyl)-N-(3-bromophenyl)benzamide?

The CAS number of 3-(azepan-1-ylsulfonyl)-N-(3-bromophenyl)benzamide is 420831-40-9.

What are the molecular formula and molecular weight of 3-(azepan-1-ylsulfonyl)-N-(3-bromophenyl)benzamide?

3-(azepan-1-ylsulfonyl)-N-(3-bromophenyl)benzamide has molecular formula C19H21BrN2O3S and molecular weight 437.351 g/mol.

Is 3-(azepan-1-ylsulfonyl)-N-(3-bromophenyl)benzamide hazardous?

3-(azepan-1-ylsulfonyl)-N-(3-bromophenyl)benzamide has GHS signal word Warning and hazard statements H319 — Causes serious eye irritation.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "3-(azepan-1-ylsulfonyl)-N-(3-bromophenyl)benzamide (CAS 420831-40-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1977831-6 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.