4-Hydroxytolbutamide

Also known as: 1-Butyl-3-(4-hydroxymethylphenyl)sulfonylurea, 1-Butyl-3-(p-hydroxymethylphenyl)sulfonylurea, 1-butyl-3-[4-(hydroxymethyl)phenyl]sulfonylurea, 4-OH-tolbutamide, 4-Hydroxytolbutamide, Benzenesulfonamide, N-[(butylamino)carbonyl]-4-(hydroxymethyl)-, Hydroxytolbutamide, N-(Butylaminocarbonyl)-4-hydroxymethylbenzenesulfonamide, N-(Butylcarbamoyl)-4-(hydroxymethyl)benzenesulfonamide, HydroxyMethylcarbutaMide, Methylhydroxytolbutamide, hydroxymethyltolbutamide, hydroxymethyl-TB, [14C]-Hydroxytolbutamide

4-Hydroxytolbutamide (CAS 5719-85-7) is a compound in the Solvents category listed in the Jingsj chemical database. It has the molecular formula C12H18N2O4S and a molecular weight of 286.347 g/mol. Key properties include a melting point of 100-102ºC, a density of 1.3±0.1 g/cm3 and a flash point of 2℃. It is classified under GHS with signal word Danger and hazard statements H225 — Highly flammable liquid and vapour, H302 — Harmful if swallowed and H312 — Harmful in contact with skin. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 5719-85-7
Jingsj CID: J-1977215-7
Molecular Formula: C₁₂H₁₈N₂O₄S
Molecular Weight: 286.347 g/mol
Category: Solvents
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	100-102ºC
Density	1.3±0.1 g/cm3
Flash Point	2℃
Exact Mass	286.098724
PSA	103.88000
LogP	0.70
Refractive Index	1.553
Storage Conditions	2-8°C
Additional Property	ethanol: 12 mg/mL

GHS Safety & Compliance

Flammable / IrritantSignal word: Danger

H225 — Highly flammable liquid and vapour
H302 — Harmful if swallowed
H312 — Harmful in contact with skin
H332 — Harmful if inhaled
H319 — Causes serious eye irritation

Activity & Biological Data

Target	Potassium channel
Additional Information	[1]. Hansen LL, et al. Quantitative determination of tolbutamide and its metabolites in human plasma and urine by high-performance liquid chromatography and UV detection. Ther Drug Monit. 1999 Dec;21(6):664-71. [2]. Yuan R, et al. Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions. Drug Metab Dispos. 2002 Dec;30(12):1311-9.

Target

Potassium channel

Additional Information

[1]. Hansen LL, et al. Quantitative determination of tolbutamide and its metabolites in human plasma and urine by high-performance liquid chromatography and UV detection. Ther Drug Monit. 1999 Dec;21(6):664-71. [2]. Yuan R, et al. Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions. Drug Metab Dispos. 2002 Dec;30(12):1311-9.

Frequently Asked Questions

What is the CAS number of 4-Hydroxytolbutamide?

The CAS number of 4-Hydroxytolbutamide is 5719-85-7.

What are the molecular formula and molecular weight of 4-Hydroxytolbutamide?

4-Hydroxytolbutamide has molecular formula C12H18N2O4S and molecular weight 286.347 g/mol.

Is 4-Hydroxytolbutamide hazardous?

4-Hydroxytolbutamide has GHS signal word Danger and hazard statements H225 — Highly flammable liquid and vapour; H302 — Harmful if swallowed; H312 — Harmful in contact with skin.

What are the upstream and downstream products of 4-Hydroxytolbutamide?

For 4-Hydroxytolbutamide, Upstream Products: Tolbutamide, Methyl 4-sulfamoylbenzoate, 1-Isocyanatobutane.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "4-Hydroxytolbutamide (CAS 5719-85-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1977215-7 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.