Donepezil hydrochloride monohydrate

Also known as: Donepezil, Donepezil base, Aricept, 2-[(1-Benzyl-4-piperidinyl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one, E-2020, MFCD00912833

Donepezil hydrochloride monohydrate (CAS 120014-06-4) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C24H29NO3 and a molecular weight of 379.492 g/mol. Key properties include a melting point of 207ºC, a boiling point of 527.9±50.0 °C at 760 mmHg, a density of 1.1±0.1 g/cm3 and a flash point of 273.1±30.1 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 120014-06-4
Jingsj CID: J-1975715-4
Molecular Formula: C₂₄H₂₉NO₃
Molecular Weight: 379.492 g/mol
Category: Organic Acids
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	207ºC
Boiling Point	527.9±50.0 °C at 760 mmHg
Density	1.1±0.1 g/cm3
Flash Point	273.1±30.1 °C
Exact Mass	379.214752
PSA	38.77000
LogP	4.71
Vapor Pressure	0.0±1.4 mmHg at 25°C
Refractive Index	1.578
Additional Property	2.931 mg/L

Activity & Biological Data

Additional Information	[1]. Ogura, H., et al., Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods Find Exp Clin Pharmacol, 2000. 22(8): p. 609-13. [2]. Snape, M.F., et al., A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066. Neuropharmacology, 1999. 38(1): p. 181-93. [3]. Huang, Z.H., et al., Donepezil protects endothelial cells against hydrogen peroxide-induced cell injury. CNS Neurosci Ther, 2012. 18(2): p. 185-7.

Additional Information

[1]. Ogura, H., et al., Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods Find Exp Clin Pharmacol, 2000. 22(8): p. 609-13. [2]. Snape, M.F., et al., A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066. Neuropharmacology, 1999. 38(1): p. 181-93. [3]. Huang, Z.H., et al., Donepezil protects endothelial cells against hydrogen peroxide-induced cell injury. CNS Neurosci Ther, 2012. 18(2): p. 185-7.

Frequently Asked Questions

What is the CAS number of Donepezil hydrochloride monohydrate?

The CAS number of Donepezil hydrochloride monohydrate is 120014-06-4.

What are the molecular formula and molecular weight of Donepezil hydrochloride monohydrate?

Donepezil hydrochloride monohydrate has molecular formula C24H29NO3 and molecular weight 379.492 g/mol.

What are the upstream and downstream products of Donepezil hydrochloride monohydrate?

For Donepezil hydrochloride monohydrate, Upstream Products: Benzyl bromide, 5,6-Dimethoxy-2-(piperidin-4-ylmethyl)-2,3-dihydro-1H-inden-1-one, 2-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one; Downstream Products: 6-O-Desmethyl donepezil, Dihydro Donepezil (Mixture of Diastereomers), 5,6-Dimethoxy-2-(piperidin-4-ylmethyl)-2,3-dihydro-1H-inden-1-one.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Donepezil hydrochloride monohydrate (CAS 120014-06-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1975715-4 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.