Wedelolactone

Also known as: 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c][1]benzopyran-6-one, 1,8,9-Trihydroxy-3-methoxy-6H-[1]benzofuro[3,2-c]chromen-6-one, 5,11,12-Trihydroxy-7-methoxycoumestan, IKK Inhibitor II, Wedelolactone (IKK inhibitor)

Wedelolactone (CAS 524-12-9) is a compound in the Esters category listed in the Jingsj chemical database. It has the molecular formula C16H10O7 and a molecular weight of 314.246 g/mol. Key properties include a melting point of 315 °C, a boiling point of 498.4±45.0 °C at 760 mmHg, a density of 1.7±0.1 g/cm3 and a flash point of 255.2±28.7 °C. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed and H317 — May cause an allergic skin reaction. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 524-12-9
Jingsj CID: J-1975661-5
Molecular Formula: C₁₆H₁₀O₇
Molecular Weight: 314.246 g/mol
Category: Esters
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	315 °C
Boiling Point	498.4±45.0 °C at 760 mmHg
Density	1.7±0.1 g/cm3
Flash Point	255.2±28.7 °C
Exact Mass	314.042664
PSA	113.27000
LogP	2.75
Vapor Pressure	0.0±1.3 mmHg at 25°C
Refractive Index	1.759
Storage Conditions	2-8°C
Additional Property	DMSO: 14 mg/mL, soluble

GHS Safety & Compliance

IrritantSignal word: Warning

H302 — Harmful if swallowed
H317 — May cause an allergic skin reaction

Activity & Biological Data

Target	Caspase-11 5-lipoxygenase:2.5 μM (IC50) Apoptosis
Additional Information	[1]. Kobori M, et al. Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex. Cell Death Differ. 2004 Jan;11(1):123-30. [2]. Sarveswaran S, et al. Wedelolactone, a medicinal plant-derived coumestan, induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Int J Oncol. 2012 Dec;41(6):2191-9. [3]. Liu YQ, et al. Wedelolactone enhances osteoblastogenesis by regulating Wnt/β-catenin signaling pathway but suppresses osteoclastogenesis by NF-κB/c-fos/NFATc1 pathway. Sci Rep. 2016 Aug 25;6:32260.

Target

Caspase-11 5-lipoxygenase:2.5 μM (IC50) Apoptosis

Additional Information

[1]. Kobori M, et al. Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex. Cell Death Differ. 2004 Jan;11(1):123-30. [2]. Sarveswaran S, et al. Wedelolactone, a medicinal plant-derived coumestan, induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Int J Oncol. 2012 Dec;41(6):2191-9. [3]. Liu YQ, et al. Wedelolactone enhances osteoblastogenesis by regulating Wnt/β-catenin signaling pathway but suppresses osteoclastogenesis by NF-κB/c-fos/NFATc1 pathway. Sci Rep. 2016 Aug 25;6:32260.

Customs & Trade Information

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Wedelolactone?

The CAS number of Wedelolactone is 524-12-9.

What are the molecular formula and molecular weight of Wedelolactone?

Wedelolactone has molecular formula C16H10O7 and molecular weight 314.246 g/mol.

Is Wedelolactone hazardous?

Wedelolactone has GHS signal word Warning and hazard statements H302 — Harmful if swallowed; H317 — May cause an allergic skin reaction.

What are the upstream and downstream products of Wedelolactone?

For Wedelolactone, Upstream Products: 3,4-Dibenzyloxybenzaldehyde, 3,4-Dihydroxybenzaldehyde.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Wedelolactone (CAS 524-12-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1975661-5 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.