AEE788

Also known as: NVP-AEE788, AEE-788, (R)-6-(4-((4-Ethylpiperazin-1-yl)methyl)phenyl)-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, 6-[4-[(4-ethyl-1-piperazinyl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 6-[4-[(4-ethyl-1-piperazinyl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-

AEE788 (CAS 497839-62-0) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C27H32N6 and a molecular weight of 440.583 g/mol. Key properties include a melting point of 247 °C and a density of 1.2±0.1 g/cm3. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 497839-62-0
Jingsj CID: J-1975437-1
Molecular Formula: C₂₇H₃₂N₆
Molecular Weight: 440.583 g/mol
Category: Pharma Intermediates
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	247 °C
Density	1.2±0.1 g/cm3
Exact Mass	440.268860
PSA	63.31000
LogP	4.76
Refractive Index	1.665

Activity & Biological Data

Target	EGFR:2 nM (IC50) ErbB2:6 nM (IC50)
Additional Information	[1]. Traxler P, et al. AEE788: a dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity. Cancer Res. 2004 Jul 15;64(14):4931-4941. [2]. Park et al. AEE788, a dual tyrosine kinase receptor inhibitor, induces endothelial cell apoptosis in human cutaneous squamous cell carcinoma xenografts in nude mice. Clin Cancer Res. 2005 Mar 1;11(5):1963-1973.

Target

EGFR:2 nM (IC50) ErbB2:6 nM (IC50)

Additional Information

[1]. Traxler P, et al. AEE788: a dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity. Cancer Res. 2004 Jul 15;64(14):4931-4941. [2]. Park et al. AEE788, a dual tyrosine kinase receptor inhibitor, induces endothelial cell apoptosis in human cutaneous squamous cell carcinoma xenografts in nude mice. Clin Cancer Res. 2005 Mar 1;11(5):1963-1973.

Frequently Asked Questions

What is the CAS number of AEE788?

The CAS number of AEE788 is 497839-62-0.

What are the molecular formula and molecular weight of AEE788?

AEE788 has molecular formula C27H32N6 and molecular weight 440.583 g/mol.

What are the upstream and downstream products of AEE788?

For AEE788, Upstream Products: 1-Ethylpiperazine.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "AEE788 (CAS 497839-62-0)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1975437-1 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.