Entinostat
Also known as: MS-275, SNDX-275, MS 275, MS275, N-[[4-[[(2-Aminophenyl)amino]carbonyl]phenyl]methyl]carbamic acid 3-pyridinylmethyl ester, Pyridin-3-ylmethyl {4-[(2-aminophenyl)carbamoyl]benzyl}carbamate, CS-189, NSC 706995
Entinostat (CAS 209783-80-2) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C21H20N4O3 and a molecular weight of 376.409 g/mol. Key properties include a melting point of 159-160ºC, a boiling point of 566.7±50.0 °C at 760 mmHg, a density of 1.3±0.1 g/cm3 and a flash point of 296.6±30.1 °C. It is classified under GHS with signal word Danger and hazard statements H301 — Toxic if swallowed, H315 — Causes skin irritation and H319 — Causes serious eye irritation. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 209783-80-2
- Jingsj CID
- J-1975412-2
- Molecular Formula
- C21H20N4O3
- Molecular Weight
- 376.409 g/mol
- Category
- Organic Compounds
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 159-160ºC |
|---|---|
| Boiling Point | 566.7±50.0 °C at 760 mmHg |
| Density | 1.3±0.1 g/cm3 |
| Flash Point | 296.6±30.1 °C |
| Exact Mass | 376.153534 |
| PSA | 106.34000 |
| LogP | 1.46 |
| Appearance | solid |
| Vapor Pressure | 0.0±1.6 mmHg at 25°C |
| Refractive Index | 1.672 |
| Storage Conditions | −20°C |
| Additional Property | DMSO: 38 mg/mL, soluble |
GHS Safety & Compliance
- H301 — Toxic if swallowed
- H315 — Causes skin irritation
- H319 — Causes serious eye irritation
- H335 — May cause respiratory irritation
- H360 — May damage fertility or the unborn child
Activity & Biological Data
| Target | HDAC1:243 nM (IC50) HDAC3:248 nM (IC50) HDAC2:453 nM (IC50) |
|---|---|
| Additional Information | [1]. Lauffer BE, et al. Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability. J Biol Chem. 2013 Sep 13;288(37):26926-43. [2]. Rosato RR, et al. The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1. Cancer Res. 2003 Jul 1;63(13):36 [3]. Saito A, et al. A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors. Proc Natl Acad Sci U S A, 1999, 96(8), 4592-4597. [4]. Zhang ZY, et al. MS-275, an histone deacetylase inhibitor, reduces the inflammatory reaction in rat experimental autoimmune neuritis. Neurosci, 2010, 169, 370-377. |
Frequently Asked Questions
What is the CAS number of Entinostat?
The CAS number of Entinostat is 209783-80-2.
What are the molecular formula and molecular weight of Entinostat?
Entinostat has molecular formula C21H20N4O3 and molecular weight 376.409 g/mol.
Is Entinostat hazardous?
Entinostat has GHS signal word Danger and hazard statements H301 — Toxic if swallowed; H315 — Causes skin irritation; H319 — Causes serious eye irritation.
What are the upstream and downstream products of Entinostat?
For Entinostat, Upstream Products: o-Phenylenediamine, 4-[(Pyridin-3-ylmethoxycarbonylamino)methyl]benzoic acid, 1,3-Dimethyl-2-imidazolidinone.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Entinostat (CAS 209783-80-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1975412-2 (accessed 2026-11-09).
Data for reference only; verify product details with suppliers before purchase.