Tasquinimod

Also known as: ABR-215050, ABR215050, 4-Hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-(4-(trifluoromethyl)phenyl)-1,2-dihydroquinoline-3-carboxamide, 1,2-dihydro-4-hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-[4-(trifluoromethyl)phenyl]-3-quinolinecarboxamide, N-Methyl-N-(4-trifluoromethylphenyl)-1,2-dihydro-4-hydroxy-5-methoxy-1-methyl-2-oxoquinoline-3-carboxamide, 3-Quinolinecarboxamide, 1,2-dihydro-4-hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-[4-(trifluoromethyl)phenyl]-, 756U07KN1R

Tasquinimod (CAS 254964-60-8) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C20H17F3N2O4 and a molecular weight of 406.355 g/mol. Key properties include a boiling point of 501.5±50.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 257.1±30.1 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 254964-60-8
Jingsj CID: J-1975272-8
Molecular Formula: C₂₀H₁₇F₃N₂O₄
Molecular Weight: 406.355 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	501.5±50.0 °C at 760 mmHg
Density	1.4±0.1 g/cm3
Flash Point	257.1±30.1 °C
Exact Mass	406.114044
PSA	71.77000
LogP	2.63
Appearance	white solid
Vapor Pressure	0.0±1.4 mmHg at 25°C
Refractive Index	1.606
Storage Conditions	-20℃

Activity & Biological Data

Target	HDAC4:10-30 nM (Kd)
Additional Information	[1]. Isaacs JT, et al. Tasquinimod Is an Allosteric Modulator of HDAC4 survival signaling within the compromised cancer microenvironment. Cancer Res. 2013 Feb 15;73(4):1386-99. [2]. Isaacs JT, et al. Anti-cancer potency of tasquinimod is enhanced via albumin-binding facilitating increased uptake in the tumor microenvironment. Oncotarget. 2014 Sep 30;5(18):8093-106. [3]. Olsson A, et al. Tasquinimod (ABR-215050), a quinoline-3-carboxamide anti-angiogenic agent, modulates the expression of thrombospondin-1 in human prostate tumors. Mol Cancer. 2010 May 17;9:107.

Target

HDAC4:10-30 nM (Kd)

Additional Information

[1]. Isaacs JT, et al. Tasquinimod Is an Allosteric Modulator of HDAC4 survival signaling within the compromised cancer microenvironment. Cancer Res. 2013 Feb 15;73(4):1386-99. [2]. Isaacs JT, et al. Anti-cancer potency of tasquinimod is enhanced via albumin-binding facilitating increased uptake in the tumor microenvironment. Oncotarget. 2014 Sep 30;5(18):8093-106. [3]. Olsson A, et al. Tasquinimod (ABR-215050), a quinoline-3-carboxamide anti-angiogenic agent, modulates the expression of thrombospondin-1 in human prostate tumors. Mol Cancer. 2010 May 17;9:107.

Frequently Asked Questions

What is the CAS number of Tasquinimod?

The CAS number of Tasquinimod is 254964-60-8.

What are the molecular formula and molecular weight of Tasquinimod?

Tasquinimod has molecular formula C20H17F3N2O4 and molecular weight 406.355 g/mol.

What are the upstream and downstream products of Tasquinimod?

For Tasquinimod, Upstream Products: N-Methyl-4-(trifluoromethyl)aniline, methyl 4-hydroxy-5-methoxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate, 2-Amino-6-methoxybenzoic acid.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Tasquinimod (CAS 254964-60-8)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1975272-8 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.