Lersivirine

Also known as: UK-453061, UK 453061, 5-((3,5-diethyl-1-(2-hydroxyethyl)-1H-pyrazol-4-yl)oxy)isophthalonitrile, 5-((3,5-diethyl-1-(2-hydroxyethyl)-1H-pyrazol-4-yl)oxy)benzene-1,3-dicarbonitrile, 5-[3,5-diethyl-1-(2-hydroxyethyl)pyrazol-4-yl]oxybenzene-1,3-dicarbonitrile, 5-{[3,5-diethyl-1-(2-hydroxyethyl)-1H-pyrazol-4-yl]oxy}isophthalonitrile, 1,3-Benzenedicarbonitrile, 5-((3,5-diethyl-1-(2-hydroxyethyl)-1H-pyrazol-4-yl)oxy)-, Lersivirine (USAN:INN)

Lersivirine (CAS 473921-12-9) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C17H18N4O2 and a molecular weight of 310.350 g/mol. Key properties include a boiling point of 455.4±45.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 229.2±28.7 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 473921-12-9
Jingsj CID: J-1975267-1
Molecular Formula: C₁₇H₁₈N₄O₂
Molecular Weight: 310.350 g/mol
Category: Pharma Intermediates
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	455.4±45.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	229.2±28.7 °C
Exact Mass	310.142975
PSA	94.86000
LogP	3.30
Vapor Pressure	0.0±1.2 mmHg at 25°C
Refractive Index	1.595
Storage Conditions	2-8℃

Activity & Biological Data

Additional Information	[1]. Mowbray CE, et al. Pyrazole NNRTIs 4: selection of UK-453,061 (lersivirine) as a development candidate. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5857-60. [2]. Davis J, et al. The effect of lersivirine, a next-generation NNRTI, on the pharmacokinetics of midazolam and oral contraceptives in healthy subjects. Eur J Clin Pharmacol. 2012 Nov;68(11):1567-72. [3]. Cappon GD, et al. Developmental toxicity study of lersivirine in mice. Birth Defects Res B Dev Reprod Toxicol. 2012 Jun;95(3):225-30.

Additional Information

[1]. Mowbray CE, et al. Pyrazole NNRTIs 4: selection of UK-453,061 (lersivirine) as a development candidate. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5857-60. [2]. Davis J, et al. The effect of lersivirine, a next-generation NNRTI, on the pharmacokinetics of midazolam and oral contraceptives in healthy subjects. Eur J Clin Pharmacol. 2012 Nov;68(11):1567-72. [3]. Cappon GD, et al. Developmental toxicity study of lersivirine in mice. Birth Defects Res B Dev Reprod Toxicol. 2012 Jun;95(3):225-30.

Frequently Asked Questions

What is the CAS number of Lersivirine?

The CAS number of Lersivirine is 473921-12-9.

What are the molecular formula and molecular weight of Lersivirine?

Lersivirine has molecular formula C17H18N4O2 and molecular weight 310.350 g/mol.

What are the upstream and downstream products of Lersivirine?

For Lersivirine, Upstream Products: 2-Hydroxyethylhydrazine.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Lersivirine (CAS 473921-12-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1975267-1 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.