Onalespib

Also known as: AT13387, AT-13387, (2,4-dihydroxy-5-isopropylphenyl)(5-((4-Methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone, [1,3-Dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]methanone, UNII-Q7Y33N57ZZ

Onalespib (CAS 912999-49-6) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C24H31N3O3 and a molecular weight of 409.521 g/mol. Key properties include a boiling point of 605.7±55.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 320.1±31.5 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 912999-49-6
Jingsj CID: J-1975260-4
Molecular Formula: C₂₄H₃₁N₃O₃
Molecular Weight: 409.521 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

Request MSDS / TDS

No offers for this compound yet.

Request a quote

Physicochemical Properties

Boiling Point	605.7±55.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	320.1±31.5 °C
Exact Mass	409.236542
PSA	67.25000
LogP	1.52
Vapor Pressure	0.0±1.8 mmHg at 25°C
Refractive Index	1.633
Storage Conditions	-20℃

Activity & Biological Data

Target	HSP90:0.71 nM (Kd)
Additional Information	[1]. Woodhead AJ, et al. Discovery of (2,4-dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a novel inhibitor of the molecular chaperone Hsp90 by fragment based drug design. J Med Chem. 2010 Aug 26;53(16):5956-69. [2]. Kang MH, et al. Initial testing (Stage 1) of AT13387, an HSP90 inhibitor, by the pediatric preclinical testing program. Pediatr Blood Cancer. 2012 Jul 15;59(1):185-8.

Target

HSP90:0.71 nM (Kd)

Additional Information

[1]. Woodhead AJ, et al. Discovery of (2,4-dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a novel inhibitor of the molecular chaperone Hsp90 by fragment based drug design. J Med Chem. 2010 Aug 26;53(16):5956-69. [2]. Kang MH, et al. Initial testing (Stage 1) of AT13387, an HSP90 inhibitor, by the pediatric preclinical testing program. Pediatr Blood Cancer. 2012 Jul 15;59(1):185-8.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Onalespib?

The CAS number of Onalespib is 912999-49-6.

What are the molecular formula and molecular weight of Onalespib?

Onalespib has molecular formula C24H31N3O3 and molecular weight 409.521 g/mol.

What are the upstream and downstream products of Onalespib?

For Onalespib, Upstream Products: 5-Bromoisoindoline, 4-Bromophthalimide, tert-Butyl 5-bromoisoindoline-2-carboxylate.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Onalespib (CAS 912999-49-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1975260-4 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.