![Molecular structure of 2-[[5-[3-(dimethylamino)propyl]-2-methyl-3-pyridinyl]amino]-5,7-dihydro-9-(trifluoromethyl)-6H-pyrimido[5,4-d][1]benzazepine-6-thione (CAS 1228960-69-7)](/images/chem_structures_svg/362/1228960-69-7.svg)
2-[[5-[3-(dimethylamino)propyl]-2-methyl-3-pyridinyl]amino]-5,7-dihydro-9-(trifluoromethyl)-6H-pyrimido[5,4-d][1]benzazepine-6-thione
Also known as: MLN0905, MLN-0905, MLN 0905, PLK1 Inhibitor, CS-1458, 2-[[5-[3-(dimethylamino)propyl]-2-methylpyridin-3-yl]amino]-9-(trifluoromethyl)-5,7-dihydropyrimido[5,4-d][1]benzazepine-6-thione
2-[[5-[3-(dimethylamino)propyl]-2-methyl-3-pyridinyl]amino]-5,7-dihydro-9-(trifluoromethyl)-6H-pyrimido[5,4-d][1]benzazepine-6-thione (CAS 1228960-69-7) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C24H25F3N6S and a molecular weight of 486.556 g/mol. Key properties include a boiling point of 624.4±65.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 331.4±34.3 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 1228960-69-7
- Jingsj CID
- J-1975256-8
- Molecular Formula
- C24H25F3N6S
- Molecular Weight
- 486.556 g/mol
- Category
- Pharma Intermediates
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Boiling Point | 624.4±65.0 °C at 760 mmHg |
|---|---|
| Density | 1.4±0.1 g/cm3 |
| Flash Point | 331.4±34.3 °C |
| Exact Mass | 486.181335 |
| PSA | 105.10000 |
| LogP | 4.60 |
| Vapor Pressure | 0.0±1.8 mmHg at 25°C |
| Refractive Index | 1.640 |
| Storage Conditions | -20℃ |
Activity & Biological Data
| Target | PLK1:2 nM (IC50) |
|---|---|
| Additional Information | [1]. Duffey MO, et al. Discovery of a potent and orally bioavailable benzolactam-derived inhibitor of Polo-like kinase 1 (MLN0905). J Med Chem. 2012 Jan 12;55(1):197-208. [2]. Shi JQ, et al. MLN0905, a small-molecule plk1 inhibitor, induces antitumor responses in human models of diffuse large B-cell lymphoma. Mol Cancer Ther. 2012 Sep;11(9):2045-53. |
Frequently Asked Questions
What is the CAS number of 2-[[5-[3-(dimethylamino)propyl]-2-methyl-3-pyridinyl]amino]-5,7-dihydro-9-(trifluoromethyl)-6H-pyrimido[5,4-d][1]benzazepine-6-thione?
The CAS number of 2-[[5-[3-(dimethylamino)propyl]-2-methyl-3-pyridinyl]amino]-5,7-dihydro-9-(trifluoromethyl)-6H-pyrimido[5,4-d][1]benzazepine-6-thione is 1228960-69-7.
What are the molecular formula and molecular weight of 2-[[5-[3-(dimethylamino)propyl]-2-methyl-3-pyridinyl]amino]-5,7-dihydro-9-(trifluoromethyl)-6H-pyrimido[5,4-d][1]benzazepine-6-thione?
2-[[5-[3-(dimethylamino)propyl]-2-methyl-3-pyridinyl]amino]-5,7-dihydro-9-(trifluoromethyl)-6H-pyrimido[5,4-d][1]benzazepine-6-thione has molecular formula C24H25F3N6S and molecular weight 486.556 g/mol.
What are the upstream and downstream products of 2-[[5-[3-(dimethylamino)propyl]-2-methyl-3-pyridinyl]amino]-5,7-dihydro-9-(trifluoromethyl)-6H-pyrimido[5,4-d][1]benzazepine-6-thione?
For 2-[[5-[3-(dimethylamino)propyl]-2-methyl-3-pyridinyl]amino]-5,7-dihydro-9-(trifluoromethyl)-6H-pyrimido[5,4-d][1]benzazepine-6-thione, Upstream Products: Methyl 2-amino-4-(trifluoromethyl)benzoate.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "2-[[5-[3-(dimethylamino)propyl]-2-methyl-3-pyridinyl]amino]-5,7-dihydro-9-(trifluoromethyl)-6H-pyrimido[5,4-d][1]benzazepine-6-thione (CAS 1228960-69-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1975256-8 (accessed 2026-11-09).
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