AMG-517

Also known as: AM -517, AMG517, AcetaMide, N-[4-[[6-[4-(trifluoroMethyl)phenyl]-4-pyriMidinyl]oxy]-2-benzothiazolyl]-, Acetamide, N-[4-[[6-[4-(trifluoromethyl)phenyl]-4-pyrimidinyl]oxy]-2-benzothiazolyl]-, Amg 517, BD-0082, CS-691, N-(4-((6-(4-(Trifluoromethyl)phenyl)pyrimidin-4-yl)oxy)benzo[d]thiazol-2-yl)acetamide, N-(4-(6-(4-(trifluoromethyl)phenyl)pyrimidin-4-yloxy)benzo[d]thiazol-2-yl)acetamide, N-(4-(6-(4-trifluoromethylphenyl)pyrimidin-4-yloxy)benzothiazol-2-yl)acetamide, N-(4-[6-(4-trifluoromethyl-phenyl)-pyrimidin-4-yloxy]-benzothiazol-2-yl)-acetamide, N-[4-({6-[4-(Trifluoromethyl)phenyl]-4-pyrimidinyl}oxy)-1,3-benzothiazol-2-yl]acetamide, N-[4-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}oxy)-1,3-benzothiazol-2-yl]acetamide, N-[4-[6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]oxy-1,3-benzothiazol-2-yl]acetamide, N-[4-[[6-[4-(Trifluoromethyl)phenyl]-4-pyrimidinyl]oxy]-2-benzothiazolyl]acetamide, N-[4-[[6-[4-(Trifluoromethyl)phenyl]-4-pyrimidinyl]oxy]-2-benzothiazolyl]acetamide AMG517, N-[4-[[6-[4-(trifluoromethyl)phenyl]-4-pyrimidinyl]oxy]-2-benzothiazolyl]-acetamide, UNII-172V4FBZ75

AMG-517 (CAS 659730-32-2) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C20H13F3N4O2S and a molecular weight of 430.403 g/mol. Key properties include a melting point of 227ºC and a density of 1.5±0.1 g/cm3. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 659730-32-2
Jingsj CID: J-1975255-7
Molecular Formula: C₂₀H₁₃F₃N₄O₂S
Molecular Weight: 430.403 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	227ºC
Density	1.5±0.1 g/cm3
Exact Mass	430.071136
PSA	108.73000
LogP	5.41
Refractive Index	1.645
Storage Conditions	-20℃

Activity & Biological Data

Target	IC50: 0.5 nM (TRPV1)[1]
Additional Information	[1]. Doherty EM, et al. Novel vanilloid receptor-1 antagonists: 2. Structure-activity relationships of 4-oxopyrimidines leading to the selection of a clinical candidate. J Med Chem. 2007 Jul 26;50(15):3515-27. [2]. Gavva NR, et al. Repeated administration of vanilloid receptor TRPV1 antagonists attenuates hyperthermia elicited by TRPV1 blockade. J Pharmacol Exp Ther. 2007 Oct;323(1):128-37.

Frequently Asked Questions

What is the CAS number of AMG-517?

The CAS number of AMG-517 is 659730-32-2.

What are the molecular formula and molecular weight of AMG-517?

AMG-517 has molecular formula C20H13F3N4O2S and molecular weight 430.403 g/mol.

What are the upstream and downstream products of AMG-517?

For AMG-517, Upstream Products: 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine, 2-Amino-4-hydroxybenzothiazole.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "AMG-517 (CAS 659730-32-2)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1975255-7 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.