2'-Hydroxy-2-methoxychalcone

Also known as: 1-(2-Hydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one, (E)-1-(2-hydroxyphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one, 2-(2-Methoxybenzylidene)-2'-hydroxyacetophenone, 2-Propen-1-one, 1-(2-hydroxyphenyl)-3-(2-methoxyphenyl)-

2'-Hydroxy-2-methoxychalcone (CAS 42220-77-9) is a compound in the Ketones category listed in the Jingsj chemical database. It has the molecular formula C16H14O3 and a molecular weight of 254.28100 g/mol. Key properties include a melting point of 112-113ºC, a boiling point of 430.6ºC at 760 mmHg, a density of 1.197g/cm3 and a flash point of 161.1ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 42220-77-9
Jingsj CID: J-1974869-7
Molecular Formula: C₁₆H₁₄O₃
Molecular Weight: 254.28100 g/mol
Category: Ketones
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	112-113ºC
Boiling Point	430.6ºC at 760 mmHg
Density	1.197g/cm3
Flash Point	161.1ºC
Exact Mass	254.09400
PSA	46.53000
LogP	3.29690
Refractive Index	1.631

Activity & Biological Data

Additional Information	[1]. Witold Gładkowski, et al. Synthesis and Antimicrobial Activity of Methoxy- Substituted γ-Oxa-ε-lactones Derived from Flavanones. Molecules. 2019 Nov 16;24(22):4151.

Customs & Trade Information

HS Code	2914509090
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Frequently Asked Questions

What is the CAS number of 2'-Hydroxy-2-methoxychalcone?

The CAS number of 2'-Hydroxy-2-methoxychalcone is 42220-77-9.

What are the molecular formula and molecular weight of 2'-Hydroxy-2-methoxychalcone?

2'-Hydroxy-2-methoxychalcone has molecular formula C16H14O3 and molecular weight 254.28100 g/mol.

What are the upstream and downstream products of 2'-Hydroxy-2-methoxychalcone?

For 2'-Hydroxy-2-methoxychalcone, Downstream Products: 3-hydroxy-2'-methoxyflavone, 2'-Methoxyflavone, 3,2'-Dihydroxyflavone.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "2'-Hydroxy-2-methoxychalcone (CAS 42220-77-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1974869-7 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.