Dantrolene

Also known as: 1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidinedione, 1-[(E)-[5-(4-nitrophenyl)furan-2-yl]methylideneamino]imidazolidine-2,4-dione, 1-[5-(4-nitro-phenyl)-furan-2-ylmethyleneamino]-imidazolidine-2,4-dione, Dantrium, Dantrium Intravenous, Dantroleno, Dantrolenum

Dantrolene (CAS 7261-97-4) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C14H10N4O5 and a molecular weight of 314.25300 g/mol. Key properties include a melting point of 279-280°C (lit.), a boiling point of 175-177ºC and a density of 1.57 g/cm3. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 7261-97-4
Jingsj CID: J-1974368-1
Molecular Formula: C₁₄H₁₀N₄O₅
Molecular Weight: 314.25300 g/mol
Category: Organic Compounds
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	279-280°C (lit.)
Boiling Point	175-177ºC
Density	1.57 g/cm3
Exact Mass	314.06500
PSA	120.73000
LogP	2.53040
Refractive Index	1.715

Activity & Biological Data

Additional Information	[1]. W J Meyler, et al. The effect of dantrolene sodium on rat skeletal muscle in relation to the plasma concentration. Eur J Pharmacol. 1979 Feb 1;53(4):335-42. [2]. F Zhao, et al. Dantrolene inhibition of ryanodine receptor Ca2+ release channels. Molecular mechanism and isoform selectivity. J Biol Chem. 2001 Apr 27;276(17):13810-6. [3]. Murat Sentürk, et al. Dantrolene inhibits human erythrocyte glutathione reductase. Biol Pharm Bull. 2008 Nov;31(11):2036-9. [4]. Shigeki Kobayashi, et al. Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing interdomain interactions within the ryanodine receptor. J Am Coll Cardiol. 2009 May 26;53(21):1993-2005. [5]. Xi Chen, et al. Dantrolene is neuroprotective in Huntington's disease transgenic mouse model. Mol Neurodegener. 2011 Nov 25;6:81.

Additional Information

[1]. W J Meyler, et al. The effect of dantrolene sodium on rat skeletal muscle in relation to the plasma concentration. Eur J Pharmacol. 1979 Feb 1;53(4):335-42. [2]. F Zhao, et al. Dantrolene inhibition of ryanodine receptor Ca2+ release channels. Molecular mechanism and isoform selectivity. J Biol Chem. 2001 Apr 27;276(17):13810-6. [3]. Murat Sentürk, et al. Dantrolene inhibits human erythrocyte glutathione reductase. Biol Pharm Bull. 2008 Nov;31(11):2036-9. [4]. Shigeki Kobayashi, et al. Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing interdomain interactions within the ryanodine receptor. J Am Coll Cardiol. 2009 May 26;53(21):1993-2005. [5]. Xi Chen, et al. Dantrolene is neuroprotective in Huntington's disease transgenic mouse model. Mol Neurodegener. 2011 Nov 25;6:81.

Frequently Asked Questions

What is the CAS number of Dantrolene?

The CAS number of Dantrolene is 7261-97-4.

What are the molecular formula and molecular weight of Dantrolene?

Dantrolene has molecular formula C14H10N4O5 and molecular weight 314.25300 g/mol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Dantrolene (CAS 7261-97-4)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1974368-1 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.