Proxyphylline

Also known as: 7-(2-Hydroxypropyl)theophylline, 1,3-Dimethyl-7-(2-hydroxypropyl)xanthine, 7-(β-Hydroxypropyl)theophylline, 7-(2-hydroxypropyl)-1,3-dimethylpurine-2,6-dione, Diprophylline EP Impurity D, Diprophylline Impurity 4, Monophylline, Spasmolysin, Proxylphylline

Proxyphylline (CAS 603-00-9) is a compound in the Organic Bases category listed in the Jingsj chemical database. It has the molecular formula C10H14N4O3 and a molecular weight of 238.24300 g/mol. Key properties include a melting point of 134-136ºC, a boiling point of 487.2ºC, a density of 1.46 g/cm3 and a flash point of 248.5ºC. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 603-00-9
Jingsj CID: J-1974089-7
Molecular Formula: C₁₀H₁₄N₄O₃
Molecular Weight: 238.24300 g/mol
Category: Organic Bases
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	134-136ºC
Boiling Point	487.2ºC
Density	1.46 g/cm3
Flash Point	248.5ºC
Exact Mass	238.10700
PSA	82.05000
Refractive Index	1.664
Storage Conditions	Refrigerator

GHS Safety & Compliance

IrritantSignal word: Warning

H302 — Harmful if swallowed

Activity & Biological Data

Additional Information	[1]. Takeda K, et al. Effects of aminophylline, proxyphylline and a proxyphylline-Melilotus extract-rutin mixture(theoesberiven) on the heart and the coronary circulation. Jpn J Pharmacol. 1977 Oct;27(5):709-20. [2]. Kukovetz WR, et al. Overadditive synergism between theophylline, diprophylline and proxyphylline in tracheal smooth muscle relaxation. Arzneimittelforschung. 1983;33(10):1450-4. [3]. Rasmussen FV, et al. Pharmacokinetics and bronchodilatory effect of proxyphylline and theophylline. Eur J Respir Dis. 1984 Jan;65(1):20-7. [4]. Selvig K, et al. Inhibition of human lung cyclic nucleotide phosphodiesterases by proxyphylline, theophylline and their metabolites. Acta Pharmacol Toxicol (Copenh). 1982 Sep;51(3):250-2.

Additional Information

[1]. Takeda K, et al. Effects of aminophylline, proxyphylline and a proxyphylline-Melilotus extract-rutin mixture(theoesberiven) on the heart and the coronary circulation. Jpn J Pharmacol. 1977 Oct;27(5):709-20. [2]. Kukovetz WR, et al. Overadditive synergism between theophylline, diprophylline and proxyphylline in tracheal smooth muscle relaxation. Arzneimittelforschung. 1983;33(10):1450-4. [3]. Rasmussen FV, et al. Pharmacokinetics and bronchodilatory effect of proxyphylline and theophylline. Eur J Respir Dis. 1984 Jan;65(1):20-7. [4]. Selvig K, et al. Inhibition of human lung cyclic nucleotide phosphodiesterases by proxyphylline, theophylline and their metabolites. Acta Pharmacol Toxicol (Copenh). 1982 Sep;51(3):250-2.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Proxyphylline?

The CAS number of Proxyphylline is 603-00-9.

What are the molecular formula and molecular weight of Proxyphylline?

Proxyphylline has molecular formula C10H14N4O3 and molecular weight 238.24300 g/mol.

Is Proxyphylline hazardous?

Proxyphylline has GHS signal word Warning and hazard statements H302 — Harmful if swallowed.

What are the upstream and downstream products of Proxyphylline?

For Proxyphylline, Upstream Products: Theophylline, 1-bromo-2-propanol, 1-Chloro-2-propanol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Proxyphylline (CAS 603-00-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1974089-7 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.