Propafenone

Also known as: 1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-1-propanone, (RS)-Propafenone, 1-[2-(2-hydroxy-3-propylamino-propoxy)phenyl]-3-phenyl-propan-1-one, 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-1-propanone, WZ-884-642, WZ-884-643

Propafenone (CAS 54063-53-5) is a compound in the Ketones category listed in the Jingsj chemical database. It has the molecular formula C21H27NO3 and a molecular weight of 341.44400 g/mol. Key properties include a melting point of 171 - 174ºC, a density of 1.096 g/cm3 and a flash point of 268ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 54063-53-5
Jingsj CID: J-1974084-3
Molecular Formula: C₂₁H₂₇NO₃
Molecular Weight: 341.44400 g/mol
Category: Ketones
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	171 - 174ºC
Density	1.096 g/cm3
Flash Point	268ºC
Exact Mass	341.19900
PSA	58.56000
LogP	3.63230
Refractive Index	1.557
Storage Conditions	2-8°C

Activity & Biological Data

Additional Information	[1]. J T Lee, et al. The role of genetically determined polymorphic drug metabolism in the beta-blockade produced by propafenone. N Engl J Med. 1990 Jun 21;322(25):1764-8. [2]. A Seki, et al. Effects of propafenone on K currents in human atrial myocytes. Br J Pharmacol. 1999 Mar;126(5):1153-62. [3]. Wei-Bin Zheng, et al. Propafenone suppresses esophageal cancer proliferation through inducing mitochondrial dysfunction. Am J Cancer Res. 2017 Nov 1;7(11):2245-2256.

Additional Information

[1]. J T Lee, et al. The role of genetically determined polymorphic drug metabolism in the beta-blockade produced by propafenone. N Engl J Med. 1990 Jun 21;322(25):1764-8. [2]. A Seki, et al. Effects of propafenone on K currents in human atrial myocytes. Br J Pharmacol. 1999 Mar;126(5):1153-62. [3]. Wei-Bin Zheng, et al. Propafenone suppresses esophageal cancer proliferation through inducing mitochondrial dysfunction. Am J Cancer Res. 2017 Nov 1;7(11):2245-2256.

Frequently Asked Questions

What is the CAS number of Propafenone?

The CAS number of Propafenone is 54063-53-5.

What are the molecular formula and molecular weight of Propafenone?

Propafenone has molecular formula C21H27NO3 and molecular weight 341.44400 g/mol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Propafenone (CAS 54063-53-5)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1974084-3 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.