N-(2-Phenylethyl)indomethacin Amide

Also known as: N-(2-PHENYLETHYL)-INDOMETHACIN AMIDE, 1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-N-(2-phenylethyl)-1H-indole-3-acetaMide, 1H-Indole-3-acetamide, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-N-(2-phenylethyl)-, 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-N-(2-phenylethyl)acetamide, 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]-N-(2-phenylethyl)acetamide, Indomethacin N-Phenylethyl Impurity, LM 4108, N-(2-PHENYLETHYL)-1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETAMIDE, N-(2-PHENYLETHYL)-1-P-CHLOROBENZOYL-5-METHOXY-2-METHYLINDOLE-3-ACETAMIDE, N-2PIA

N-(2-Phenylethyl)indomethacin Amide (CAS 261766-32-9) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C27H25ClN2O3 and a molecular weight of 460.95 g/mol. Key properties include a boiling point of 640.5±55.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 341.2±31.5 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 261766-32-9
Jingsj CID: J-1973533-2
Molecular Formula: C₂₇H₂₅ClN₂O₃
Molecular Weight: 460.95 g/mol
Category: Pharma Intermediates
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	640.5±55.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	341.2±31.5 °C
Exact Mass	460.155365
PSA	63.82000
LogP	4.31
Vapor Pressure	0.0±1.9 mmHg at 25°C
Refractive Index	1.613

Activity & Biological Data

Target	Human COX-2:60 nM (IC50) Ovine COX-1:>66 μM (IC50)
Additional Information	[1]. Rory P Remmel, et al. Studies on the metabolism of the novel, selective cyclooxygenase-2 inhibitor indomethacin phenethylamide in rat, mouse, and human liver microsomes: identification of active metabolites. Drug Metab Dispos. 2004 Jan;32(1):113-22. [2]. Remmel R P, et al. Studies on the metabolism of the novel, selective cyclooxygenase-2 inhibitor indomethacin phenethylamide in rat, mouse, and human liver microsomes: identification of active metabolites. Drug metabolism and disposition, 2004, 32(1): 113-122.

Target

Human COX-2:60 nM (IC50) Ovine COX-1:>66 μM (IC50)

Additional Information

[1]. Rory P Remmel, et al. Studies on the metabolism of the novel, selective cyclooxygenase-2 inhibitor indomethacin phenethylamide in rat, mouse, and human liver microsomes: identification of active metabolites. Drug Metab Dispos. 2004 Jan;32(1):113-22. [2]. Remmel R P, et al. Studies on the metabolism of the novel, selective cyclooxygenase-2 inhibitor indomethacin phenethylamide in rat, mouse, and human liver microsomes: identification of active metabolites. Drug metabolism and disposition, 2004, 32(1): 113-122.

Frequently Asked Questions

What is the CAS number of N-(2-Phenylethyl)indomethacin Amide?

The CAS number of N-(2-Phenylethyl)indomethacin Amide is 261766-32-9.

What are the molecular formula and molecular weight of N-(2-Phenylethyl)indomethacin Amide?

N-(2-Phenylethyl)indomethacin Amide has molecular formula C27H25ClN2O3 and molecular weight 460.95 g/mol.

What are the upstream and downstream products of N-(2-Phenylethyl)indomethacin Amide?

For N-(2-Phenylethyl)indomethacin Amide, Upstream Products: Indometacin.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "N-(2-Phenylethyl)indomethacin Amide (CAS 261766-32-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1973533-2 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.