Lomerizine hydrochloride
Also known as: Lomerizine dihydrochloride, KB-2796, Terranas, Flometizine hydrochloride, 1-[Bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]piperazine dihydrochloride, 1-(Bis(4-fluorophenyl)methyl)-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride, Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]-, hydrochloride (1:2)
Lomerizine hydrochloride (CAS 101477-54-7) is a compound in the Organic Acids category listed in the Jingsj chemical database. It has the molecular formula C27H32Cl2F2N2O3 and a molecular weight of 541.457 g/mol. Key properties include a melting point of 214-218ºC, a boiling point of 527.3ºC at760mmHg and a flash point of 272.7ºC. It is classified under GHS with signal word Warning and hazard statements H302 — Harmful if swallowed and H410 — Very toxic to aquatic life with long lasting effects. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.
- CAS No.
- 101477-54-7
- Jingsj CID
- J-1972975-0
- Molecular Formula
- C27H32Cl2F2N2O3
- Molecular Weight
- 541.457 g/mol
- Category
- Organic Acids
- Last updated
- 8/21/2026
No offers for this compound yet.
Request a quotePhysicochemical Properties
| Melting Point | 214-218ºC |
|---|---|
| Boiling Point | 527.3ºC at760mmHg |
| Flash Point | 272.7ºC |
| Exact Mass | 540.175781 |
| PSA | 34.17000 |
| LogP | 6.37760 |
| Storage Conditions | -20°C Freezer |
GHS Safety & Compliance
- H302 — Harmful if swallowed
- H410 — Very toxic to aquatic life with long lasting effects
Activity & Biological Data
| Target | T-type calcium channel L-type calcium channel |
|---|---|
| Additional Information | [1]. Tran LT, et al. The voltage-gated calcium channel blocker Lomerizine is neuroprotective in motor neurons expressing mutant SOD1, but not TDP-43. J Neurochem. 2014 Aug;130(3):455-66. [2]. Zhu HJ, et al. [Reversal of multidrug resistance by Lomerizine in K562/ADM cells]. Yao Xue Xue Bao. 2004 May;39(5):333-7. [3]. Nakamura-Yanagidaira T, et al. Development of spontaneous neuropathy in NF-κBp50-deficient mice by calcineurin-signal involving impaired NF-κB activation. Mol Vis. 2011;17:2157-70. [4]. Shimazawa M, et al. Effects of Ca2+ channel blockers on cortical hypoperfusion and expression of c-Fos-like immunoreactivity after cortical spreading depression in rats. Br J Pharmacol. 1995 Aug;115(8):1359-68. |
Frequently Asked Questions
What is the CAS number of Lomerizine hydrochloride?
The CAS number of Lomerizine hydrochloride is 101477-54-7.
What are the molecular formula and molecular weight of Lomerizine hydrochloride?
Lomerizine hydrochloride has molecular formula C27H32Cl2F2N2O3 and molecular weight 541.457 g/mol.
Is Lomerizine hydrochloride hazardous?
Lomerizine hydrochloride has GHS signal word Warning and hazard statements H302 — Harmful if swallowed; H410 — Very toxic to aquatic life with long lasting effects.
What are the upstream and downstream products of Lomerizine hydrochloride?
For Lomerizine hydrochloride, Upstream Products: 1-(chloromethyl)-2,3,4-trimethoxybenzene, 1-[bis(4-fluorophenyl)methyl]piperazine, 2,3,4-Trimethoxybenzaldehyde.
Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.
Last updated:
How to cite: Jingsj. "Lomerizine hydrochloride (CAS 101477-54-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1972975-0 (accessed 2026-11-06).
Data for reference only; verify product details with suppliers before purchase.