Glaucine

Also known as: BOLDINE DIMETHYL ETHER, (+)-Glaucine, d-Glaucine, bromcholitin, glauvent, Nsc34396, (S)-Glaucine, (6aS)-1,2,9,10-Tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline, 1,2,9,10-TETRAMETHOXYAPORPHINE, 4H-Dibenzo[de,g]quinoline, 5,6,6a,7-tetrahydro-1,2,9,10-tetramethoxy-6-methyl-, (6aS)-, EINECS 207-501-5

Glaucine (CAS 475-81-0) is a compound in the Organic Bases category listed in the Jingsj chemical database. It has the molecular formula C21H25NO4 and a molecular weight of 355.427 g/mol. Key properties include a melting point of 246-247ºC, a boiling point of 487.0±45.0 °C at 760 mmHg, a density of 1.2±0.1 g/cm3 and a flash point of 140.2±25.9 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 475-81-0
Jingsj CID: J-1972252-8
Molecular Formula: C₂₁H₂₅NO₄
Molecular Weight: 355.427 g/mol
Category: Organic Bases
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	246-247ºC
Boiling Point	487.0±45.0 °C at 760 mmHg
Density	1.2±0.1 g/cm3
Flash Point	140.2±25.9 °C
Exact Mass	355.178345
PSA	40.16000
LogP	3.86
Vapor Pressure	0.0±1.2 mmHg at 25°C
Refractive Index	1.576

Activity & Biological Data

Target	Ki: 3.4 µM (Phosphodiesterase 4 (PDE4))[1] α-adrenoceptor[1] Ca2+ channel[1] Dopamine D1/D2 receptors[2]
Additional Information	[1]. J Cortijo, et al. Bronchodilator and Anti-Inflammatory Activities of Glaucine: In Vitro Studies in Human Airway Smooth Muscle and Polymorphonuclear Leukocytes. Br J Pharmacol. 1999 Aug;127(7):1641-51. [2]. Golo M J Meyer, et al. Studies on the in Vivo Contribution of Human Cytochrome P450s to the Hepatic Metabolism of Glaucine, a New Drug of Abuse. Biochem Pharmacol. 2013 Nov 15;86(10):1497-506. [3]. Maya Spasova, et al. Cinnamoyl- And Hydroxycinnamoyl Amides of Glaucine and Their Antioxidative and Antiviral Activities. Bioorg Med Chem. 2008 Aug 1;16(15):7457-61.

Target

Ki: 3.4 µM (Phosphodiesterase 4 (PDE4))[1] α-adrenoceptor[1] Ca2+ channel[1] Dopamine D1/D2 receptors[2]

Additional Information

[1]. J Cortijo, et al. Bronchodilator and Anti-Inflammatory Activities of Glaucine: In Vitro Studies in Human Airway Smooth Muscle and Polymorphonuclear Leukocytes. Br J Pharmacol. 1999 Aug;127(7):1641-51. [2]. Golo M J Meyer, et al. Studies on the in Vivo Contribution of Human Cytochrome P450s to the Hepatic Metabolism of Glaucine, a New Drug of Abuse. Biochem Pharmacol. 2013 Nov 15;86(10):1497-506. [3]. Maya Spasova, et al. Cinnamoyl- And Hydroxycinnamoyl Amides of Glaucine and Their Antioxidative and Antiviral Activities. Bioorg Med Chem. 2008 Aug 1;16(15):7457-61.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of Glaucine?

The CAS number of Glaucine is 475-81-0.

What are the molecular formula and molecular weight of Glaucine?

Glaucine has molecular formula C21H25NO4 and molecular weight 355.427 g/mol.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "Glaucine (CAS 475-81-0)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1972252-8 (accessed 2026-11-06).

Data for reference only; verify product details with suppliers before purchase.