1-(6-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine

Also known as: 1-(6-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine, 1-[6-chloro-5-(trifluoromethyl)-2-pyridyl]piperazine, Org 12962, Org12962, Piperazine, 1-[6-chloro-5-(trifluoromethyl)-2-pyridinyl]-

1-(6-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine (CAS 132834-56-1) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C10H11ClF3N3 and a molecular weight of 265.66300 g/mol. Key properties include a boiling point of 286.004ºC at 760 mmHg, a density of 1.454g/cm3 and a flash point of 126.771ºC. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 132834-56-1
Jingsj CID: J-1971850-4
Molecular Formula: C₁₀H₁₁ClF₃N₃
Molecular Weight: 265.66300 g/mol
Category: Pharma Intermediates
Last updated: 8/21/2026

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Physicochemical Properties

Boiling Point	286.004ºC at 760 mmHg
Density	1.454g/cm3
Flash Point	126.771ºC
Exact Mass	265.05900
PSA	28.16000
LogP	2.55720
Vapor Pressure	0.001mmHg at 25°C
Refractive Index	1.541

Activity & Biological Data

Target	5-HT2C Receptor:7.01 (pEC50) 5-HT2A Receptor:6.38 (pEC50) 5-HT2B Receptor:6.28 (pEC50)
Additional Information	[1]. Porter RH,et al. Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells.Br J Pharmacol. 1999 Sep;128(1):13-20. [2]. Jenck F, et al. Antiaversive effects of 5HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats.Eur Neuropsychopharmacol. 1998 Aug;8(3):161-8. [3]. Faassen F, et al. Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs.Int J Pharm. 2003 Sep 16;263(1-2):113-22.

Target

5-HT2C Receptor:7.01 (pEC50) 5-HT2A Receptor:6.38 (pEC50) 5-HT2B Receptor:6.28 (pEC50)

Additional Information

[1]. Porter RH,et al. Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells.Br J Pharmacol. 1999 Sep;128(1):13-20. [2]. Jenck F, et al. Antiaversive effects of 5HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats.Eur Neuropsychopharmacol. 1998 Aug;8(3):161-8. [3]. Faassen F, et al. Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs.Int J Pharm. 2003 Sep 16;263(1-2):113-22.

Customs & Trade Information

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Frequently Asked Questions

What is the CAS number of 1-(6-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine?

The CAS number of 1-(6-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine is 132834-56-1.

What are the molecular formula and molecular weight of 1-(6-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine?

1-(6-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine has molecular formula C10H11ClF3N3 and molecular weight 265.66300 g/mol.

What are the upstream and downstream products of 1-(6-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine?

For 1-(6-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine, Upstream Products: Piperazine, 2,6-Dichloro-3-(trifluoromethyl)pyridine.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "1-(6-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine (CAS 132834-56-1)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1971850-4 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.