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BI 2536

Also known as: (R)-4-((8-cyclopentyl-7-ethyl-5-Methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)aMino)-3-Methoxy-N-(1-Methylpiperidin-4-yl)benzaMide, (R)-4-((8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)amino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, 4-[[(7R)-8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide, 4-[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, 4-[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide,type I anhydrate, 4-[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide,type II anhydrate, 4-[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide,type III anhydrate, 4-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, 4-{[(7R)-8-Cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydro-2-pteridinyl]amino}-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide, BI-2536, BI-2536(R-), BI-2536, BoehringerPLK-1 inhibitor, BI2536, BI2536/BI-2536, Benzamide, 4-[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-, Benzamide, 4-[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-, Boehringer PLK-1 inhibitor, S1109_Selleck

BI 2536 (CAS 755038-02-9) is a compound in the Organic Compounds category listed in the Jingsj chemical database. It has the molecular formula C28H39N7O3 and a molecular weight of 521.654 g/mol. Key property: a density of 1.3±0.1 g/cm3. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.
755038-02-9
Jingsj CID
J-1971627-9
Molecular Formula
C28H39N7O3
Molecular Weight
521.654 g/mol
Category
Organic Compounds
Last updated
8/21/2026
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Physicochemical Properties

Density1.3±0.1 g/cm3
Exact Mass521.311462
PSA102.93000
LogP1.81
Refractive Index1.634
Storage Conditions-20°C

Activity & Biological Data

TargetPLK1:0.83 nM (IC50) Plk2/Snk:3.5 nM (IC50) Plk3/Fnk:9 nM (IC50) BRD4:25 nM (IC50)
Additional Information[1]. Lénárt P, et al. The Small-Molecule Inhibitor BI 2536 Reveals Novel Insights into Mitotic Roles of Polo-like Kinase 1. Curr Biol. 2007 Feb 20;17(4):304-15. [2]. Chen L, et al. BRD4 Structure-Activity Relationships of Dual PLK1 Kinase/BRD4 Bromodomain Inhibitor BI-2536. ACS Med Chem Lett. 2015 May 18;6(7):764-9. [3]. Steegmaier M, et al. BI 2536, a Potent and Selective Inhibitor of Polo-like Kinase 1, Inhibits Tumor Growth In Vivo. Current Biology (2007), 17(4), 316-322. [4]. Jeong SB, et al. Essential role of Polo-like kinase 1 (Plk1) oncogene in tumor growth and metastasis of tamoxifen-resistant breast cancer. Mol Cancer Ther. 2018 Apr;17(4):825-837.

Frequently Asked Questions

What is the CAS number of BI 2536?

The CAS number of BI 2536 is 755038-02-9.

What are the molecular formula and molecular weight of BI 2536?

BI 2536 has molecular formula C28H39N7O3 and molecular weight 521.654 g/mol.

What are the upstream and downstream products of BI 2536?

For BI 2536, Upstream Products: 1-Methylpiperidin-4-amine, (7R)-2-chloro-8-cyclopentyl-7-ethyl-5-methyl-7,8-dihydropteridin-6(5H)-one, Butanoic acid, 2-[(2-chloro-5-nitro-4-pyrimidinyl)cyclopentylamino]-, methyl ester, (2R)-.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated:

How to cite: Jingsj. "BI 2536 (CAS 755038-02-9)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1971627-9 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.