4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-5-(4-pyridinyl)-1H-imidazole

Also known as: SB 203580, SB203580, 4-(4-(4-Fluorophenyl)-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-5-yl)pyridine, 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole, 4-[5-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-3H-imidazol-4-yl]pyridine, 4-[5-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl]pyridine, p38 MAP kinase inhibitor XVI, RWJ 64809, MFCD00922198

4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-5-(4-pyridinyl)-1H-imidazole (CAS 152121-47-6) is a compound in the Pharma Intermediates category listed in the Jingsj chemical database. It has the molecular formula C21H16FN3OS and a molecular weight of 377.435 g/mol. Key properties include a melting point of 249 - 250ºC, a boiling point of 615.6±55.0 °C at 760 mmHg, a density of 1.4±0.1 g/cm3 and a flash point of 326.1±31.5 °C. It is classified under GHS with signal word Danger and hazard statements H302 — Harmful if swallowed and H318 — Causes serious eye damage. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 152121-47-6
Jingsj CID: J-1971553-8
Molecular Formula: C₂₁H₁₆FN₃OS
Molecular Weight: 377.435 g/mol
Category: Pharma Intermediates
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	249 - 250ºC
Boiling Point	615.6±55.0 °C at 760 mmHg
Density	1.4±0.1 g/cm3
Flash Point	326.1±31.5 °C
Exact Mass	377.099823
PSA	77.85000
LogP	4.10
Vapor Pressure	0.0±1.7 mmHg at 25°C
Refractive Index	1.715
Storage Conditions	−20°C
Stability	-200C
Additional Property	DMSO: 50 mg/mL

GHS Safety & Compliance

Corrosion / IrritantSignal word: Danger

H302 — Harmful if swallowed
H318 — Causes serious eye damage

Activity & Biological Data

Target	p38 MAP kinase:0.3-0.5 μM (IC50, in IL-2-stimulated T cells) PKB:3-5 μM (IC50, in IL-2-stimulated T cells) Autophagy Mitophagy
Additional Information	[1]. Lali FV, et al. The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activated protein kinase. J Biol Chem. 2000 Mar 10;275(10):7395-402. [2]. Birkenkamp KU, et al. The p38 MAP kinase inhibitor SB203580 enhances nuclear factor-kappa B transcriptional activity by a non-specific effect upon the ERK pathway. Br J Pharmacol. 2000 Sep;131(1):99-107. [3]. Su J, et al. SB203580, a p38 inhibitor, improved cardiac function but worsened lung injury and survival during Escherichia coli pneumonia in mice. J Trauma. 2010 Jun;68(6):1317-27. [4]. Badger AM, et al. Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function. J Pharmacol Exp Ther. 1996 Dec;279(3):1453-61. [5]. Lin Y, et al. Critical role of astrocytic interleukin-17?A in post-stroke survival and neuronal differentiation of neural precursor cells in adult mice. Cell Death Dis. 2016 Jun 23;7(6):e2273.

Target

p38 MAP kinase:0.3-0.5 μM (IC50, in IL-2-stimulated T cells) PKB:3-5 μM (IC50, in IL-2-stimulated T cells) Autophagy Mitophagy

Additional Information

[1]. Lali FV, et al. The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activated protein kinase. J Biol Chem. 2000 Mar 10;275(10):7395-402. [2]. Birkenkamp KU, et al. The p38 MAP kinase inhibitor SB203580 enhances nuclear factor-kappa B transcriptional activity by a non-specific effect upon the ERK pathway. Br J Pharmacol. 2000 Sep;131(1):99-107. [3]. Su J, et al. SB203580, a p38 inhibitor, improved cardiac function but worsened lung injury and survival during Escherichia coli pneumonia in mice. J Trauma. 2010 Jun;68(6):1317-27. [4]. Badger AM, et al. Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function. J Pharmacol Exp Ther. 1996 Dec;279(3):1453-61. [5]. Lin Y, et al. Critical role of astrocytic interleukin-17?A in post-stroke survival and neuronal differentiation of neural precursor cells in adult mice. Cell Death Dis. 2016 Jun 23;7(6):e2273.

Customs & Trade Information

HS Code	2818200000

Frequently Asked Questions

What is the CAS number of 4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-5-(4-pyridinyl)-1H-imidazole?

The CAS number of 4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-5-(4-pyridinyl)-1H-imidazole is 152121-47-6.

What are the molecular formula and molecular weight of 4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-5-(4-pyridinyl)-1H-imidazole?

4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-5-(4-pyridinyl)-1H-imidazole has molecular formula C21H16FN3OS and molecular weight 377.435 g/mol.

Is 4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-5-(4-pyridinyl)-1H-imidazole hazardous?

4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-5-(4-pyridinyl)-1H-imidazole has GHS signal word Danger and hazard statements H302 — Harmful if swallowed; H318 — Causes serious eye damage.

What are the upstream and downstream products of 4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-5-(4-pyridinyl)-1H-imidazole?

For 4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-5-(4-pyridinyl)-1H-imidazole, Upstream Products: 4-Pyridinemethanol, 4-Fluorobenzoyl chloride, 4-Fluoro-N-methoxy-N-methylbenzamide.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-5-(4-pyridinyl)-1H-imidazole (CAS 152121-47-6)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1971553-8 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.