6-Demethoxytangeretin

Also known as: 4',5,7,8-Tetramethoxyflavone, 5,7,8,4'-Tetramethoxyflavone, 5,7,8-trimethoxy-2-(4-methoxyphenyl)chromen-4-one, Tetra-O-methylisoscutellarein, UNII-2U2U884D0P, tetramethylisoscutellarein

6-Demethoxytangeretin (CAS 6601-66-7) is a compound in the Ketones category listed in the Jingsj chemical database. It has the molecular formula C19H18O6 and a molecular weight of 342.343 g/mol. Key properties include a melting point of 216-217 ºC, a boiling point of 536.9±50.0 °C at 760 mmHg, a density of 1.243±0.06 g/cm3 and a flash point of 237.5±30.2 °C. No supplier offers are currently listed; request a quote. Record last updated Aug 21, 2026.

CAS No.: 6601-66-7
Jingsj CID: J-1971268-6
Molecular Formula: C₁₉H₁₈O₆
Molecular Weight: 342.343 g/mol
Category: Ketones
Last updated: 8/21/2026

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Physicochemical Properties

Melting Point	216-217 ºC
Boiling Point	536.9±50.0 °C at 760 mmHg
Density	1.243±0.06 g/cm3
Flash Point	237.5±30.2 °C
Exact Mass	342.110352
PSA	67.13000
LogP	3.06
Vapor Pressure	0.0±1.4 mmHg at 25°C
Refractive Index	1.575
Storage Conditions	2-8℃
Additional Property	Practically insoluble (0.027 g/L) (25 ºC)

Activity & Biological Data

Additional Information	[1]. Kim YM, et al. A citrus flavonoid, 6-demethoxytangeretin, suppresses production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase and mitogen-activated protein kinase pathways. Biol Pharm Bull. 2014;37(5):871-6. Epub 2014 Feb 5. [2]. Kawahata I, et al. Potent activity of nobiletin-rich Citrus reticulata peel extract to facilitate cAMP/PKA/ERK/CREB signaling associated with learning and memory in cultured hippocampal neurons: identification of the substances responsible for the pharmacological action. J Neural Transm (Vienna). 2013 Oct;120(10):1397-409.

Additional Information

[1]. Kim YM, et al. A citrus flavonoid, 6-demethoxytangeretin, suppresses production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase and mitogen-activated protein kinase pathways. Biol Pharm Bull. 2014;37(5):871-6. Epub 2014 Feb 5. [2]. Kawahata I, et al. Potent activity of nobiletin-rich Citrus reticulata peel extract to facilitate cAMP/PKA/ERK/CREB signaling associated with learning and memory in cultured hippocampal neurons: identification of the substances responsible for the pharmacological action. J Neural Transm (Vienna). 2013 Oct;120(10):1397-409.

Customs & Trade Information

HS Code	2914509090
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Frequently Asked Questions

What is the CAS number of 6-Demethoxytangeretin?

The CAS number of 6-Demethoxytangeretin is 6601-66-7.

What are the molecular formula and molecular weight of 6-Demethoxytangeretin?

6-Demethoxytangeretin has molecular formula C19H18O6 and molecular weight 342.343 g/mol.

What are the upstream and downstream products of 6-Demethoxytangeretin?

For 6-Demethoxytangeretin, Upstream Products: 4-(Benzyloxy)benzoic acid, 4-Methoxybenzoic anhydride, iodomethane; Downstream Products: Scutellarein, Isoscutellarein.

Data compiled from public chemical databases such as PubChem and supplier catalogs; supplier offers are provided by suppliers.

Last updated: 8/21/2026

How to cite: Jingsj. "6-Demethoxytangeretin (CAS 6601-66-7)". Jingsj Chemical Database. https://www.jingsj.com/compound/J-1971268-6 (accessed 2026-11-09).

Data for reference only; verify product details with suppliers before purchase.